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Drug Interaction Report

This report displays the potential drug interactions for the following 2 drugs:

  • Cycrin (medroxyprogesterone)
  • pegvaliase

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Interactions between your drugs

Moderate

medroxyPROGESTERone pegvaliase

Applies to: Cycrin (medroxyprogesterone), pegvaliase

Pegvaliase may cause severe allergic reactions, and using it together with other "PEGylated" medications (i.E., medications formulated with polyethylene glycol) may increase the risk. Some examples of PEGylated medications besides pegvaliase include: certolizumab pegol (Cimzia); doxorubicin liposomal (Doxil, Lipodox); epoetin beta-methoxy polyethylene glycol (Mircera); medroxyprogesterone acetate injectable suspension (Depo-Provera); naloxegol (Movantik); pegademase bovine (Adagen); pegaptanib (Macugen); pegaspargase (Oncaspar); pegfilgrastim (Neulasta, Fulphila); peginesatide (Omontys); peginterferons (Pegasys, PEG-Intron, Sylatron, Plegridy); pegloticase (Krystexxa); pegvisomant (Somavert); and certain recombinant products used to treat hemophilia (Adynovate, Rebinyn). Before receiving treatment with pegvaliase, let your doctor know if you are currently using other PEGylated products. Your doctor will prescribe an auto-injectable epinephrine for you (or your caregiver) to administer in case you experience a severe allergic reaction during treatment with pegvaliase. You should stop using pegvaliase and seek immediate medical attention if you develop any of the following symptoms of a severe allergic reaction: fainting; dizziness or lightheadedness; sudden confusion; trouble breathing or wheezing; chest discomfort or tightness; rapid heart rate; swelling of your face, lips, eyes, or tongue; throat tightness; flushing; rash, itching, or raised bumps on skin; nausea, vomiting, or diarrhea; and incontinence. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

There are no known alcohol/food interactions with your selected drugs. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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