Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- Cycrin (medroxyprogesterone)
- deferasirox
Interactions between your drugs
medroxyPROGESTERone deferasirox
Applies to: Cycrin (medroxyprogesterone), deferasirox
ADDITIONAL CONTRACEPTION RECOMMENDED: Coadministration with deferasirox may decrease the plasma concentrations of contraceptive hormones. The proposed mechanism is deferasirox induction of CYP450 3A4, the isoenzyme primarily responsible for the metabolic clearance of sex hormones.
MANAGEMENT: Hormonal contraceptives agents may not be reliable when used with deferasirox. Female patients of reproductive potential receiving hormonal contraceptives should be counseled to use alternative or additional methods of birth control during treatment with deferasirox.
References (1)
- (2001) "Product Information. Desferal (deferoxamine)." Novartis Pharmaceuticals
Drug and food interactions
deferasirox food
Applies to: deferasirox
ADJUST DOSING INTERVAL: According to product labeling, the bioavailability of deferasirox was variably increased when taken with a meal.
MANAGEMENT: To ensure consistent plasma drug levels, deferasirox should be taken on an empty stomach 30 minutes before eating preferably at the same time everyday.
References (1)
- (2005) "Product Information. Exjade (deferasirox)." Novartis Pharmaceuticals
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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