Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Amikin Pediatric (amikacin)
- carboplatin
Interactions between your drugs
amikacin CARBOplatin
Applies to: Amikin Pediatric (amikacin), carboplatin
GENERALLY AVOID: Combining carboplatin and aminoglycosides may increase the risk of nephro- and ototoxicity. The exact mechanism of the interaction is unknown. Both carboplatin and aminoglycosides have been reported to cause renal magnesium wasting.
MANAGEMENT: In patients currently receiving carboplatin therapy, the use of less toxic antimicrobials is preferable. If carboplatin and an aminoglycoside must be used together, renal function, auditory and vestibular function, and serum magnesium should be monitored carefully.
References (1)
- (2001) "Product Information. Paraplatin (carboplatin)." Bristol-Myers Squibb
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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