Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- lincomycin
- Parepectolin (attapulgite)
Interactions between your drugs
lincomycin attapulgite
Applies to: lincomycin, Parepectolin (attapulgite)
GENERALLY AVOID: Adsorbent antidiarrheal agents may significantly reduce the gastrointestinal absorption of oral clindamycin and lincomycin, causing decreased serum levels and potential loss of antimicrobial effectiveness. Kaolin-pectin has been associated with a 90% reduction in lincomycin levels.
MANAGEMENT: The use of adsorbent antidiarrheals should be avoided if possible. If used concurrently, the patient should be monitored closely for loss of antibiotic efficacy.
References (5)
- Albert KS, DeSante KA, Welch RD, DiSanto AR (1978) "Pharmacokinetic evaluation of a drug interaction between kaolin-pectin and clindamycin." J Pharm Sci, 67, p. 1579-82
- (2002) "Product Information. Cleocin (clindamycin)." Pharmacia and Upjohn
- (2001) "Product Information. Lincocin (lincomycin)." Pharmacia and Upjohn
- McCall CE, Steigbigel NH, Finland M (1967) "Lincomycin: activity in vitro and absorption and excretion in normal young men." Am J Med Sci, 254, p. 144-55
- McGehee RF Jr, Smith CB, Wilcox C, Finland M (1968) "Comparative studies of antibacterial activity in vitro and absorption and excretion of lincomycin and clindamycin." Am J Med Sci, 256, p. 279-92
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Report options
- Switch to consumer interaction data
- Email this report to a friend, doctor, or patient
- Ask questions, find answers
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Augmentin
Augmentin is a prescription antibiotic combining amoxicillin and clavulanate to treat bacterial ...
Cefdinir
Cefdinir is used for bacterial infection, bronchitis, middle ear infections, pneumonia, sinusitis ...
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Clindamycin
Clindamycin (Cleocin) is used to treat serious infections caused by bacteria. Includes clindamycin ...
Levofloxacin
Levofloxacin is a fluoroquinolone antibiotic used to treat serious bacterial infections and prevent ...
Cephalexin
Cephalexin is a cephalosporin antibiotic used to treat bacterial infections like respiratory, skin ...
Ceftriaxone
Ceftriaxone is used for bacteremia, bacterial endocarditis prevention, bacterial infection, bone ...
Metronidazole
Metronidazole is an antibiotic used to fight bacteria in your body. Learn about side effects ...
Ciprofloxacin
Ciprofloxacin is an antibiotic belong to a group of drugs called fluoroquinolones. Learn about side ...
Doxycycline
Doxycycline is a tetracycline antibiotic used to treat many different bacterial infections such as ...
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.