Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- lactulose
- Rowasa Sulfite Free (mesalamine)
Interactions between your drugs
lactulose mesalamine
Applies to: lactulose, Rowasa Sulfite Free (mesalamine)
Coadministration with lactulose or similar preparations may cause a reduction in the release of mesalamine from some oral tablet formulations of mesalamine. Bacterial metabolism of lactulose may lower the stool pH which may prevent the release of mesalamine from some oral tablet formulations. This interaction does not apply to all mesalamine preparations. Use of lactulose or similar preparations with certain oral tablet formulations of mesalamine should generally be avoided. Please consult the manufacturer's individual product labeling for more specific recommendations and guidance.
References (3)
- Hussain FN, Ajjan RA, Moustafa M, Weir NW, Riley SA (1998) "Mesalazine release from a pH dependent formulation: effects of omeprazole and lactulose co-administration." Br J Clin Pharmacol, 46, p. 173-5
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Cerner Multum, Inc. "Australian Product Information."
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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