Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- lactulose
- neomycin
Interactions between your drugs
neomycin lactulose
Applies to: neomycin, lactulose
On theoretical grounds and based on limited experimental data in rats, coadministration with neomycin may presumably reduce the effectiveness of lactulose in the treatment of portal-systemic encephalopathy by eliminating certain colonic bacteria necessary for the degradation of lactulose to organic acids. However, the relevance of this interaction has not been fully elucidated. Clinical data do not appear to support a significant effect of neomycin on lactulose-induced reduction of colonic pH, and concomitant use has resulted in positive effects on various therapeutic markers of portal-systemic encephalopathy.
References (4)
- Conn HO (1972) "Interactions of lactulose and neomycin." Drugs, 4, p. 4-6
- (2002) "Product Information. Chronulac (lactulose)." Hoechst Marion Roussel
- (2002) "Product Information. Cephulac (lactulose)." Hoechst Marion Roussel
- (2012) "Product Information. Enulose (lactulose)." United Research Laboratories/Mutual Pharmaceutical Company
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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