Drug Interaction Report

Ibandronate can affect kidney function and may increase the blood levels and effects of entecavir when used together. Contact your doctor if you experience increased side effects or your condition changes. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. You should seek immediate medical attention if you experience extreme tiredness or weakness, dizziness, lightheadedness, muscle pain, difficulty breathing, stomach pain, nausea, vomiting, and/or a fast or irregular heart beat, as these may be signs and symptoms of a serious medical condition known as lactic acidosis that can sometimes occur during treatment with medications like entecavir. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food may reduce the absorption of ibandronate, which may lead to lower blood levels of the medication and possibly reduced effectiveness. You should take ibandronate first thing in the morning, at least 30 minutes before you eat or drink anything or take any other medication. Take each dose with a full glass (6 to 8 ounces) of water, and use only plain water (not mineral or vitamin water). Do not take ibandronate if you cannot sit upright or stand for at least 30 minutes. Because ibandronate can cause irritation and ulcer in the stomach or esophagus (the tube that connects your mouth and stomach), you will need to stay upright for at least 30 minutes after taking this medication. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

You may experience reduced absorption of entecavir in the presence of food. Take entecavir on an empty stomach 2 hours before or 2 hours after a meal unless otherwise directed by your doctor. This will make it easier for your body to absorb the medication. It is important to take entecavir regularly to get the most benefit.