Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Fluothane (halothane)
- momelotinib
Interactions between your drugs
halothane momelotinib
Applies to: Fluothane (halothane), momelotinib
Consumer information for this interaction is not currently available.
MONITOR: Coadministration of momelotinib may increase the plasma concentrations and effects of drugs that are substrates of CYP450 2B6. The proposed mechanism, based on in vitro data, is decreased drug clearance due to momelotinib-mediated inhibition of the CYP450 2B6 isoenzyme. However, clinical data are not available.
MANAGEMENT: Caution is advised if the momelotinib is administered with sensitive substrates of CYP450 2B6. Patients should be monitored for the development of adverse effects. Dosage adjustments as well as clinical and laboratory monitoring should be considered whenever momelotinib is added to or withdrawn from therapy with these drugs. Individual product labeling for the coadministered drug may also be consulted for specific guidance.
Drug and food/lifestyle interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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