Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- gemfibrozil
- iptacopan
Interactions between your drugs
gemfibrozil iptacopan
Applies to: gemfibrozil, iptacopan
GENERALLY AVOID: Coadministration with potent inhibitors of CYP450 2C8 may significantly increase the plasma concentrations and the risk of adverse effects associated with iptacopan, which is primarily metabolized by the isoenzyme. Increased systemic exposure to iptacopan may result in an increased risk of adverse effects including potentially serious and life-threatening bacterial infections, abdominal pain, diarrhea, headache, hyperlipidemia, nasopharyngitis, nausea, rash, thrombocytopenia, and viral infection. Clinical data evaluating this interaction are not available.
MANAGEMENT: The concomitant administration of potent CYP450 2C8 inhibitors with iptacopan should generally be avoided.
References (3)
- (2024) "Product Information. Fabhalta (iptacopan)." Novartis Pharmaceuticals Australia Pty Ltd
- (2024) "Product Information. Fabhalta (iptacopan)." Novartis Pharmaceuticals, SUPPL-1
- Novartis Pharmaceuticals Canada Inc Product Monograph. Fabhalta (iptacopan) https://pdf.hres.ca/dpd_pm/00078186.PDF
Drug and food/lifestyle interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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