Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- fosphenytoin
- pemoline
Interactions between your drugs
pemoline fosphenytoin
Applies to: pemoline, fosphenytoin
MONITOR: Decreased seizure threshold has been reported in patients receiving pemoline concomitantly with antiepileptic medications. The mechanism of interaction has not been described, although convulsive seizures have been reported as a side effect of pemoline.
MANAGEMENT: Caution and clinical monitoring are advised when pemoline is used in patients receiving anticonvulsant therapy. Patients should be advised to notify their physician if they experience loss of seizure control.
References (1)
- (2001) "Product Information. Cylert (pemoline)." Abbott Pharmaceutical
Drug and food/lifestyle interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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