Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- fosphenytoin
- oxtriphylline
Interactions between your drugs
oxtriphylline fosphenytoin
Applies to: oxtriphylline, fosphenytoin
MONITOR: Phenytoin has been reported to increase the clearance of theophylline by 40% to 50%, presumably by enhancing the hepatic CYP450 metabolism of theophylline. Also, coadministration of theophylline has been reported to lower serum phenytoin concentrations. Other hydantoins and hepatically metabolized methylxanthines may also interact.
MANAGEMENT: Management consists of monitoring clinical response and serum concentrations of both drugs and adjusting dosages as necessary. Patients should be advised to report loss of seizure control or worsening of respiratory symptoms to their physician.
References (4)
- Upton RA (1991) "Pharmacokinetic interactions between theophylline and other medication (Part I)." Clin Pharmacokinet, 20, p. 66-80
- Miller M, Cosgriff J, Kwong T, Morken DA (1984) "Influence of phenytoin on theophylline clearance." Clin Pharmacol Ther, 35, p. 666-9
- Crowley JJ, Cusack BJ, Jue SG, et al. (1987) "Cigarette smoking and theophylline metabolism: effects of phenytoin." Clin Pharmacol Ther, 42, p. 334-40
- Sklar SJ, Wagner (1985) "Enhanced theophylline clearance secondary to phenytoin therapy." Drug Intell Clin Pharm, 19, p. 34-6
Drug and food/lifestyle interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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