Drug Interaction Report

Alefacept may decrease the blood levels and effects of propafenone. You may need a dose adjustment if you have been receiving propafenone and are starting treatment with alefacept. Likewise, if you have been receiving both medications, the dose of propafenone may need to be adjusted when alefacept is discontinued. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Consumption of grapefruit, grapefruit juice, and supplements that contain grapefruit should be avoided during treatment with propafenone as they may increase the blood levels of propafenone in some patients. This can cause serious side effects such as new or worsening irregular heart rhythm or heart failure; chest pain; difficulty breathing; fluid retention and swelling; and slow heart rate and pulse. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.