Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- aldesleukin
- nelfinavir
Interactions between your drugs
aldesleukin nelfinavir
Applies to: aldesleukin, nelfinavir
MONITOR: The use of aldesleukin may increase blood levels of some protease inhibitors by inhibiting their metabolism via the CYP450 3A4 pathway. Indinavir AUCs increased by 26% to 214% in 8 of 9 patients receiving concomitant therapy.
MANAGEMENT: Monitoring for signs and symptoms of protease inhibitor toxicity (e.g., hyperbilirubinemia, nausea, vomiting, diarrhea, flank pain, nephrolithiasis, urolithiasis) is recommended when aldesleukin is added or the dosage increased.
References (1)
- Piscitelli SC, Vogel S, Figg WD, et al. (1998) "Alteration in indinavir clearance during interleukin-2 infusions in patients infected with the human immunodeficiency virus." Pharmacotherapy, 18, p. 1212-6
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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