Drug Interaction Report
3 potential interactions and/or warnings found for the following 2 drugs:
- Estrace (estradiol)
- Premphase (conjugated estrogens / medroxyprogesterone)
Interactions between your drugs
No drug ⬌ drug interactions were found between the drugs in your list. However, this does not necessarily mean no drug interactions exist. Always consult your healthcare provider.
Drug and food interactions
estradiol food
Applies to: Estrace (estradiol)
Information for this minor interaction is available on the professional version.
conjugated estrogens food
Applies to: Premphase (conjugated estrogens / medroxyprogesterone)
Information for this minor interaction is available on the professional version.
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Estrogens
Therapeutic duplication
The recommended maximum number of medicines in the 'estrogens' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'estrogens' category:
- Estrace (estradiol)
- Premphase (conjugated estrogens / medroxyprogesterone)
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
Report options
- Switch to professional interaction data
- Email this report to a friend, doctor, or patient
- Ask questions, find answers
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Premarin
Premarin is used to treat symptoms of menopause such as hot flashes, and vaginal dryness. Learn ...
Estradiol Patch
Estradiol Patch is used for atrophic urethritis, atrophic vaginitis, breast cancer, palliative ...
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Vagifem
Vagifem vaginal inserts are used treat menopause symptoms such as dryness, burning, and irritation ...
Estrace Vaginal Cream
Estrace Vaginal Cream is used for atrophic urethritis, atrophic vaginitis
Prempro
Prempro (conjugated estrogens and medroxyprogesterone) is used to treat the symptoms of menopause ...
CombiPatch
CombiPatch is used for atrophic urethritis, atrophic vaginitis, hypoestrogenism, postmenopausal symptoms
Conjugated estrogens
Conjugated estrogens is used for abnormal uterine bleeding, atrophic urethritis, atrophic ...
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.