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Vosevi (sofosbuvir / velpatasvir / voxilaprevir) and Alcohol/Food Interactions

There is 1 alcohol/food/lifestyle interaction with Vosevi (sofosbuvir / velpatasvir / voxilaprevir):

Moderate

voxilaprevir food

Moderate Food Interaction

Consumer information for this interaction is not currently available.

ADJUST DOSING INTERVAL: Administration with food enhances the oral bioavailability of sofosbuvir, velpatasvir, and voxilaprevir. Relative to fasting conditions, mean sofosbuvir systemic exposure (AUC) increased by 64% to 144%, mean velpatasvir AUC increased by 40% to 166%, and mean voxilaprevir AUC increased by 112% to 435% when the combined sofosbuvir/velpatasvir/voxilaprevir formulation is administered with food.

MANAGEMENT: Sofosbuvir/velpatasvir/voxilaprevir should be administered with food.

References

  1. "Product Information. Vosevi (sofosbuvir/velpatasvir/voxilaprevir)." Gilead Sciences, Foster City, CA.

Vosevi (sofosbuvir / velpatasvir / voxilaprevir) drug interactions

There are 145 drug interactions with Vosevi (sofosbuvir / velpatasvir / voxilaprevir)

Vosevi (sofosbuvir / velpatasvir / voxilaprevir) disease interactions

There are 4 disease interactions with Vosevi (sofosbuvir / velpatasvir / voxilaprevir) which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.