Tagrisso and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with Tagrisso (osimertinib).
Caffeine Osimertinib
Moderate Drug Interaction
MONITOR: Coadministration with osimertinib may decrease the plasma concentrations of drugs that are primarily metabolized by CYP450 1A2. In vitro, osimertinib has been shown to be an inducer of the isoenzyme. However, no pharmacokinetic data are available from drug interaction studies.
MANAGEMENT: Caution is advised when osimertinib is prescribed with drugs that undergo metabolism by CYP450 1A2. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever osimertinib is added to or withdrawn from therapy. Sensitive CYP450 1A2 substrates or substrates with narrow therapeutic ranges (e.g., theophylline) should preferably be avoided with osimertinib, if possible.
References (1)
- (2015) "Product Information. Tagrisso (osimertinib)." Astra-Zeneca Pharmaceuticals
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Tagrisso drug interactions
There are 619 drug interactions with Tagrisso (osimertinib).
Tagrisso disease interactions
There are 6 disease interactions with Tagrisso (osimertinib) which include:
- cardiomyopathy
- dermatologic toxicities
- ocular disorders
- pulmonary toxicity
- QT prolongation
- renal/liver impairment
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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