Zejula and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with Zejula (niraparib).
Caffeine Niraparib
Minor Drug Interaction
Coadministration with niraparib may decrease the plasma concentrations of drugs that are substrates of the CYP450 1A2 isoenzyme. At high concentrations, niraparib is able to weakly induce CYP450 1A2. If niraparib is used in combination with substrates of CYP450 1A2, particularly those with a narrow therapeutic range (e.g., clozapine, theophylline, ropinirole), then monitoring for signs and symptoms of reduced exposure to the CYP450 1A2 substrate should be considered.
References (6)
- (2023) "Product Information. Akeega (abiraterone-niraparib)." Janssen Biotech, Inc.
- (2023) "Product Information. Zejula (niraparib)." GlaxoSmithKline
- (2023) "Product Information. Zejula (niraparib)." GlaxoSmithKline Inc
- (2023) "Product Information. Akeega (abiraterone-niraparib)." Janssen Inc
- (2023) "Product Information. Zejula (niraparib)." GlaxoSmithKline Australia Pty Ltd
- (2023) "Product Information. Zejula (niraparib)." GlaxoSmithKline UK Ltd
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Zejula drug interactions
There are 611 drug interactions with Zejula (niraparib).
Zejula disease interactions
There are 5 disease interactions with Zejula (niraparib) which include:
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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