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Talwin Nx (naloxone / pentazocine) and Alcohol / Food Interactions

There are 2 alcohol/food/lifestyle interactions with Talwin Nx (naloxone / pentazocine) which include:


naloxone ↔ Alcohol (Ethanol)

Moderate Drug Interaction

The following interaction applies only if you are taking naloxone in an injectable formulation: Using pentazocine together with naloxone can reverse the effects of pentazocine. If you are a physically dependent patient you may experience withdrawal symptoms. This can cause nausea, vomiting, diarrhea, aches, fever, runny nose, sneezing, nervousness, irritability, shivering, and abdominal cramps. Talk to your doctor if you have any questions or concerns. You may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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pentazocine ↔ Alcohol (Ethanol)

Moderate Drug Interaction

Do not use alcohol or medications that contain alcohol while you are receiving treatment with pentazocine. This may increase nervous system side effects such as drowsiness, dizziness, lightheadedness, difficulty concentrating, and impairment in thinking and judgment. In severe cases, low blood pressure, respiratory distress, fainting, coma, or even death may occur. With certain long-acting formulations of narcotic pain medication, consumption of alcohol may also cause rapid release of the drug, resulting in high blood levels that may be potentially lethal. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. Do not use more than the recommended dose of pentazocine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medication without first talking to your doctor.

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pentazocine ↔ food

Moderate Food Interaction

Consumer information for this interaction is not currently available.

MONITOR: Smoking tobacco may decrease the plasma concentrations and effects of pentazocine by enhancing its metabolic clearance.

MANAGEMENT: The possibility of reduced therapeutic effects of pentazocine should be considered in smokers.


  1. Miller LG "Recent developments in the study of the effects of cigarette smoking on clinical pharmacokinetics and clinical pharmacodynamics." Clin Pharmacokinet 17 (1989): 90-108
  2. "Product Information. Talacen (acetaminophen-pentazocine)." Sanofi-Synthelabo Inc, New York, NY.
  3. D'Arcy PF "Tobacco smoking and drugs: a clinically important interaction?" Drug Intell Clin Pharm 18 (1984): 302-7

Talwin Nx (naloxone / pentazocine) drug Interactions

There are 791 drug interactions with Talwin Nx (naloxone / pentazocine)

Talwin Nx (naloxone / pentazocine) disease Interactions

There are 18 disease interactions with Talwin Nx (naloxone / pentazocine) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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