Lapatinib and Alcohol / Food Interactions
There are 2 alcohol/food/lifestyle interactions with lapatinib which include:
lapatinib ↔ food
Moderate Food Interaction
Take lapatinib on an empty stomach 1 hour before or 1 hour after a meal unless otherwise directed by your doctor. This will make it easier for your body to absorb the medication. The lapatinib dose is administered once daily and should not be divided. The usual dose of lapatinib is equal to 5 tablets. You may swallow each tablet one at a time, but take the entire lapatinib dose at the same time each day. If you are receiving therapy with lapatinib you should be advised to avoid grapefruits and grapefruit juice. Grapefruit can raise the levels of lapatinib in your body and lead to dangerous side effects.
High Blood Pressure (Hypertension)
Moderate Potential Hazard, Moderate plausibility
HER2 inhibitors - CHF
Decreases in left ventricular ejection fraction (LVEF) have been reported with agents that block HER2 activity. Patients who have received prior anthracyclines, those who received anthracycline after stopping therapy with agents that block HER2 activity, or patients who received prior radiotherapy to the chest area may be at higher risk of decreased LVEF. Therapy with these agents should be administered cautiously in patients with prior history of heart conditions. Evaluate cardiac function before, during and upon completion of treatment. Discontinue treatment with agents that block HER2 activity as appropriate, and for a confirmed clinically significant decrease in left ventricular function, or if the LVEF has not improved or has declined further, unless the benefits for the individual patient outweigh the risks.
lapatinib drug Interactions
There are 639 drug interactions with lapatinib
lapatinib disease Interactions
There are 9 disease interactions with lapatinib which include:
- Dermatologic Toxicities
- Pulmonary Toxicity
- Qt Prolongation
- Pulmonary Toxicity
- Liver Dysfunction
- Renal Impairment
Drug Interaction Classification
Do not stop taking any medications without consulting your healthcare provider.