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Lapatinib Pregnancy and Breastfeeding Warnings

Lapatinib is also known as: Tykerb

Lapatinib Pregnancy Warnings

Lapatinib has been assigned to pregnancy category D by the FDA. Animal studies have revealed evidence of minor anomalies (left-sided umbilical artery, cervical rib, and precocious ossification) and an increased death rate. Maternal (animal) toxicity was associated with decreased fetal body weights and minor skeletal variations. There are no controlled data in human pregnancy. Lapatinib should only be given during pregnancy when there are no alternatives and benefit outweighs risk. Because lapatinib can cause fetal harm when administered to a pregnant woman, women should be advised not to become pregnant when taking lapatinib.

See references

Lapatinib Breastfeeding Warnings

There are no data on the excretion of lapatinib into human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from lapatinib, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

See references

References for pregnancy information

  1. "Product Information. Tykerb (lapatinib)." GlaxoSmithKline, Research Triangle Park, NC.

References for breastfeeding information

  1. "Product Information. Tykerb (lapatinib)." GlaxoSmithKline, Research Triangle Park, NC.

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