Levsinex and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with Levsinex (hyoscyamine).
Hyoscyamine Alcohol (Ethanol)
Moderate Drug Interaction
GENERALLY AVOID: Use of anticholinergic agents with alcohol may result in sufficient impairment of attention so as to render driving and operating machinery more hazardous. In addition, the potential for abuse may be increased with the combination. The mechanism of interaction is not established but may involve additive depressant effects on the central nervous system. No effect of oral propantheline or atropine on blood alcohol levels was observed in healthy volunteers when administered before ingestion of a standard ethanol load. However, one study found impairment of attention in subjects given atropine 0.5 mg or glycopyrrolate 1 mg in combination with alcohol.
MANAGEMENT: Alcohol should generally be avoided during therapy with anticholinergic agents. Patients should be counseled to avoid activities requiring mental alertness until they know how these agents affect them.
References (1)
- Linnoila M (1973) "Drug effects on psychomotor skills related to driving: interaction of atropine, glycopyrrhonium and alcohol." Eur J Clin Pharmacol, 6, p. 107-12
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Hyoscyamine High Blood Pressure (Hypertension)
Minor Potential Hazard, Low plausibility
anticholinergics - hypertension
Cardiovascular effects of anticholinergics may exacerbate hypertension. Therapy with anticholinergic agents should be administered cautiously in patients with hypertension.
References (7)
- (2002) "Product Information. Benadryl (diphenhydramine)." Parke-Davis
- (2001) "Product Information. Antivert (meclizine)." Roerig Division
- (2001) "Product Information. Marezine (cyclizine)." Glaxo Wellcome
- Valentin N, Staffeldt H, Kyst A (1984) "Effect of i.v. atropine on cardiac rhythm, heart rate, blood pressure and airway secretion during isoflurane anaesthesia." Acta Anaesthesiol Scand, 28, p. 621-4
- (2022) "Product Information. Atropine Sulfate (atropine)." ESI Lederle Generics
- (2001) "Product Information. Artane (trihexyphenidyl)." Lederle Laboratories
- (2002) "Product Information. Atropisol (atropine ophthalmic)." Ciba Vision Ophthalmics
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Levsinex drug interactions
There are 208 drug interactions with Levsinex (hyoscyamine).
Levsinex disease interactions
There are 19 disease interactions with Levsinex (hyoscyamine) which include:
- autonomic neuropathy
- GI obstruction
- glaucoma
- obstructive uropathy
- reactive airway diseases
- myasthenia gravis
- infectious diarrhea
- cardiac disease
- tachycardia
- coronary artery disease
- gastric ulcer
- gastroesophageal reflux
- ulcerative colitis
- liver disease
- renal failure
- hypertension
- hyperthyroidism
- diarrhea
- fever
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More about Levsinex (hyoscyamine)
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- Drug class: anticholinergics/antispasmodics
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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