Solu-Cortef and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with Solu-Cortef (hydrocortisone).
Hydrocortisone High Blood Pressure (Hypertension)
Moderate Potential Hazard, Moderate plausibility
corticosteroids - fluid retention
Corticosteroids may cause hypernatremia, hypokalemia, fluid retention, and elevation in blood pressure. Large doses of any corticosteroid can demonstrate these effects, particularly if given for longer periods. Therapy with corticosteroids should be administered cautiously in patients with preexisting fluid retention, hypertension, congestive heart failure, and/or renal dysfunction. Dietary sodium restriction and potassium supplementation may be advisable.
Hydrocortisone High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)
Moderate Potential Hazard, Moderate plausibility
corticosteroids - hyperlipidemia
Corticosteroids may elevate serum triglyceride and LDL cholesterol levels if used for longer than brief periods. Patients with preexisting hyperlipidemia may require closer monitoring during prolonged corticosteroid therapy, and adjustments made accordingly in their lipid-lowering regimen.
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Solu-Cortef drug interactions
There are 640 drug interactions with Solu-Cortef (hydrocortisone).
Solu-Cortef disease interactions
There are 23 disease interactions with Solu-Cortef (hydrocortisone) which include:
- infections
- prematurity
- (+) tuberculin test
- cirrhosis
- depression/psychoses
- diabetes
- electrolyte imbalance
- fluid retention
- GI perforation
- hyperadrenocorticalism
- hyperlipidemia
- hypothyroidism
- liver disease
- MI
- myasthenia gravis
- myopathy
- ocular herpes simplex
- ocular toxicities
- osteoporosis
- PUD
- scleroderma
- strongyloidiasis
- thromboembolism
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- Drug class: glucocorticoids
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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