Nextstellis and Alcohol/Food Interactions
There are 4 alcohol/food/lifestyle interactions with Nextstellis (drospirenone / estetrol).
Drospirenone Food
Moderate Food Interaction
Consumer information for this interaction is not currently available.
MONITOR: Grapefruit juice may increase the plasma concentrations of orally administered drugs that are substrates of the CYP450 3A4 isoenzyme. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit. Because grapefruit juice inhibits primarily intestinal rather than hepatic CYP450 3A4, the magnitude of interaction is greatest for those drugs that undergo significant presystemic metabolism by CYP450 3A4 (i.e., drugs with low oral bioavailability). In general, the effect of grapefruit juice is concentration-, dose- and preparation-dependent, and can vary widely among brands. Certain preparations of grapefruit juice (e.g., high dose, double strength) have sometimes demonstrated potent inhibition of CYP450 3A4, while other preparations (e.g., low dose, single strength) have typically demonstrated moderate inhibition. Pharmacokinetic interactions involving grapefruit juice are also subject to a high degree of interpatient variability, thus the extent to which a given patient may be affected is difficult to predict.
MANAGEMENT: Patients who regularly consume grapefruit or grapefruit juice should be monitored for adverse effects and altered plasma concentrations of drugs that undergo significant presystemic metabolism by CYP450 3A4. Grapefruit and grapefruit juice should be avoided if an interaction is suspected. Orange juice is not expected to interact with these drugs.
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Estetrol High Blood Pressure (Hypertension)
Major Potential Hazard, Moderate plausibility
estrogens - hypertension
The risk of myocardial infarction and strokes, including those associated with oral contraceptive use and some estrogen use, is increased in patients with hypertension. Moreover, estrogens (and progestogens) may elevate blood pressure and worsen the hypertension, thus compounding the risk. Clinically significant blood pressure increases have been reported during estrogen therapy, particularly in patients receiving high dosages or treated with oral contraceptive combinations having high progestational activity. These effects also increase with duration of therapy and patient age. Therapy with estrogens should be administered cautiously in patients with preexisting hypertension. Patients should be monitored for changes in cardiovascular status, and their antihypertensive regimen adjusted or estrogen therapy withdrawn as necessary. In patients requiring contraception, alternative methods should be considered for those who are hypertensive, over age 35, and smoke.
Estetrol Obesity
Moderate Potential Hazard, Moderate plausibility
estetrol - obesity
The combination oral contraceptive drospirenone-estetrol, has been shown to be less effective in females with a body mass index (BMI) of 30 kg/m2 or higher. Decreasing efficacy may be associated with increasing BMI. The safety and efficacy of drospirenone-estetrol have not been adequately evaluated in females with a BMI 35 kg/m2 or higher.
Estetrol High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)
Moderate Potential Hazard, Moderate plausibility
estrogens - hyperlipidemia
Although estrogens have generally favorable effects on plasma lipids, including increases in HDL and decreases in total cholesterol and LDL, they have also been associated with significant elevations in triglyceride levels, particularly when high dosages are used. Severe hyperlipidemia is known to sometimes cause pancreatitis. Patients with preexisting hyperlipidemia may require closer monitoring during estrogen therapy, and adjustments made accordingly in their lipid-lowering regimen.
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Nextstellis drug interactions
There are 524 drug interactions with Nextstellis (drospirenone / estetrol).
Nextstellis disease interactions
There are 17 disease interactions with Nextstellis (drospirenone / estetrol) which include:
- smoking
- hyperkalemia
- abnormal vaginal bleeding
- carcinomas (estrogenic)
- hypertension
- thromboembolism/cardiovascular
- hepatic neoplasms
- obesity
- angioedema
- gallbladder disease
- hyperlipidemia
- liver disease
- melasma
- depression
- glucose intolerance
- retinal thrombosis
- thyroid function tests
More about Nextstellis (drospirenone / estetrol)
- Nextstellis consumer information
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- Reviews (28)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- FDA approval history
- Drug class: contraceptives
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.