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Butorphanol and Alcohol/Food Interactions

There are 2 alcohol/food/lifestyle interactions with butorphanol.


butorphanol Alcohol (Ethanol)

Moderate Drug Interaction

Do not use alcohol or medications that contain alcohol while you are receiving treatment with butorphanol. This may increase nervous system side effects such as drowsiness, dizziness, lightheadedness, difficulty concentrating, and impairment in thinking and judgment. In severe cases, low blood pressure, respiratory distress, fainting, coma, or even death may occur. With certain long-acting formulations of narcotic pain medication, consumption of alcohol may also cause rapid release of the drug, resulting in high blood levels that may be potentially lethal. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. Do not use more than the recommended dose of butorphanol, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medication without first talking to your doctor.

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High Blood Pressure (Hypertension)

Moderate Potential Hazard, Moderate plausibility

butorphanol - hypertension

Butorphanol may increase blood pressure and rarely causes severe hypertension. Therapy with butorphanol should be administered cautiously in hypertensive patients, particularly when given before surgery or anesthesia.


  1. "Product Information. Stadol (butorphanol nasal)." Bristol-Myers Squibb (2001):
  2. "Product Information. Stadol (butorphanol)." Allscrips Pharmaceutical Company (2001):

Butorphanol drug interactions

There are 514 drug interactions with butorphanol.

Butorphanol disease interactions

There are 17 disease interactions with butorphanol which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.