Bupivacaine/dexamethasone/epinephrine and Alcohol/Food Interactions
There are 3 alcohol/food/lifestyle interactions with bupivacaine / dexamethasone / epinephrine.
Epinephrine Caffeine
Moderate Drug Interaction
MONITOR: Coadministration of two or more sympathomimetic agents may increase the risk of adverse effects such as nervousness, irritability, and increased heart rate. Central nervous system (CNS) stimulants, particularly amphetamines, can potentiate the adrenergic response to vasopressors and other sympathomimetic agents. Additive increases in blood pressure and heart rate may occur due to enhanced peripheral sympathetic activity.
MANAGEMENT: Caution is advised if two or more sympathomimetic agents are coadministered. Pulse and blood pressure should be closely monitored.
References (7)
- Rosenblatt JE, Lake CR, van Kammen DP, Ziegler MG, Bunney WE Jr (1979) "Interactions of amphetamine, pimozide, and lithium on plasma norepineophrine and dopamine-beta-hydroxylase in schizophrenic patients." Psychiatry Res, 1, p. 45-52
- Cavanaugh JH, Griffith JD, Oates JA (1970) "Effect of amphetamine on the pressor response to tyramine: formation of p-hydroxynorephedrine from amphetamine in man." Clin Pharmacol Ther, 11, p. 656
- (2001) "Product Information. Adderall (amphetamine-dextroamphetamine)." Shire Richwood Pharmaceutical Company Inc
- (2001) "Product Information. Tenuate (diethylpropion)." Aventis Pharmaceuticals
- (2001) "Product Information. Sanorex (mazindol)." Novartis Pharmaceuticals
- (2001) "Product Information. Focalin (dexmethylphenidate)." Mikart Inc
- (2002) "Product Information. Strattera (atomoxetine)." Lilly, Eli and Company
Switch to consumer interaction data
Dexamethasone High Blood Pressure (Hypertension)
Moderate Potential Hazard, Moderate plausibility
corticosteroids - fluid retention
Corticosteroids may cause hypernatremia, hypokalemia, fluid retention, and elevation in blood pressure. Large doses of any corticosteroid can demonstrate these effects, particularly if given for longer periods. Therapy with corticosteroids should be administered cautiously in patients with preexisting fluid retention, hypertension, congestive heart failure, and/or renal dysfunction. Dietary sodium restriction and potassium supplementation may be advisable.
References (11)
- (2001) "Product Information. Hydeltrasol (prednisolone)." Merck & Co., Inc
- (2001) "Product Information. Deltasone (prednisone)." Pharmacia and Upjohn
- (2001) "Product Information. Decadron (dexamethasone)." Merck & Co., Inc
- (2001) "Product Information. Hydrocortone (hydrocortisone)." Merck & Co., Inc
- (2001) "Product Information. Medrol (methylprednisolone)." Pharmacia and Upjohn
- (2001) "Product Information. Florinef Acetate (fludrocortisone)." Bristol-Myers Squibb
- (2001) "Product Information. Cortone Acetate (cortisone)." Merck & Co., Inc
- (2001) "Product Information. Kenalog (triamcinolone)." Bristol-Myers Squibb
- (2001) "Product Information. Celestone (betamethasone)." Schering Corporation
- (2021) "Product Information. Emflaza (deflazacort)." PTC Therapeutics, Inc., SUPPL-5
- (2023) "Product Information. Agamree (vamorolone)." Santhera Pharmaceuticals (US)
Dexamethasone High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)
Moderate Potential Hazard, Moderate plausibility
corticosteroids - hyperlipidemia
Corticosteroids may elevate serum triglyceride and LDL cholesterol levels if used for longer than brief periods. Patients with preexisting hyperlipidemia may require closer monitoring during prolonged corticosteroid therapy, and adjustments made accordingly in their lipid-lowering regimen.
References (10)
- Seale JP, Compton MR (1986) "Side-effects of corticosteroid agents." Med J Aust, 144, p. 139-42
- (2001) "Product Information. Hydeltrasol (prednisolone)." Merck & Co., Inc
- (2001) "Product Information. Deltasone (prednisone)." Pharmacia and Upjohn
- (2001) "Product Information. Decadron (dexamethasone)." Merck & Co., Inc
- (2001) "Product Information. Hydrocortone (hydrocortisone)." Merck & Co., Inc
- (2001) "Product Information. Medrol (methylprednisolone)." Pharmacia and Upjohn
- (2001) "Product Information. Florinef Acetate (fludrocortisone)." Bristol-Myers Squibb
- (2001) "Product Information. Cortone Acetate (cortisone)." Merck & Co., Inc
- (2001) "Product Information. Kenalog (triamcinolone)." Bristol-Myers Squibb
- (2001) "Product Information. Celestone (betamethasone)." Schering Corporation
Switch to consumer interaction data
Bupivacaine/dexamethasone/epinephrine drug interactions
There are 1015 drug interactions with bupivacaine / dexamethasone / epinephrine.
Bupivacaine/dexamethasone/epinephrine disease interactions
There are 31 disease interactions with bupivacaine / dexamethasone / epinephrine which include:
- infections
- prematurity
- cardiovascular disease
- dehydration
- cardiovascular disease
- liver disease
- renal impairment
- (+) tuberculin test
- cirrhosis
- depression/psychoses
- diabetes
- electrolyte imbalance
- fluid retention
- GI perforation
- hyperadrenocorticalism
- hyperlipidemia
- hypothyroidism
- liver disease
- MI
- myasthenia gravis
- myopathy
- ocular herpes simplex
- ocular toxicities
- osteoporosis
- PUD
- scleroderma
- strongyloidiasis
- thromboembolism
- parkinson's disease
- acidosis
- diabetes
Report options
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.