Drug Interactions between prednisone and Ubrelvy
This report displays the potential drug interactions for the following 2 drugs:
- prednisone
- Ubrelvy (ubrogepant)
Interactions between your drugs
No interactions were found between prednisone and Ubrelvy. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
prednisone
A total of 588 drugs are known to interact with prednisone.
- Prednisone is in the drug class glucocorticoids.
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Prednisone is used to treat the following conditions:
- Acute Lymphocytic Leukemia
- Adrenocortical Insufficiency
- Adrenogenital Syndrome
- Allergic Reactions
- Allergic Rhinitis
- Allergies
- Amyloidosis
- Ankylosing Spondylitis
- Aspiration Pneumonia
- Asthma
- Atopic Dermatitis
- Autoimmune Hemolytic Anemia
- Berylliosis
- Bullous Pemphigoid
- Bursitis
- Chorioretinitis
- Cluster Headaches
- Cogan's Syndrome
- Conjunctivitis, Allergic
- COPD
- Corneal Ulcer
- Crohn's Disease, Active
- Dermatitis Herpetiformis
- Dermatomyositis
- Diffuse Large B-Cell Lymphoma
- Eczema
- Epicondylitis, Tennis Elbow
- Erythroblastopenia
- Fibromyalgia
- Food Allergies
- Giant Cell Arteritis
- Gouty Arthritis
- Graft-versus-host disease
- Herpes Zoster
- Herpes Zoster Iridocyclitis
- Hypercalcemia of Malignancy
- Immune Thrombocytopenia
- Immunosuppression
- Inflammatory Bowel Disease
- Inflammatory Conditions
- Interstitial Lung Disease
- Iridocyclitis
- Iritis
- Juvenile Rheumatoid Arthritis
- Keratitis
- Leukemia
- Lichen Planopilaris
- Lichen Planus
- Lichen Sclerosus
- Loeffler's Syndrome
- Lupus
- Lupus Nephritis
- Lymphoma
- Mixed Connective Tissue Disease
- Multiple Sclerosis
- Mycosis Fungoides
- Nephrotic Syndrome
- Neurosarcoidosis
- Optic Neuritis
- Osteoarthritis
- Pemphigoid
- Pemphigus
- Pharyngitis
- Polymyalgia Rheumatica
- Polymyositis/Dermatomyositis
- Psoriasis
- Psoriatic Arthritis
- Ramsay Hunt Syndrome
- Rheumatoid Arthritis
- Sarcoidosis
- Scleroderma
- Seborrheic Dermatitis
- Sinusitis
- Skin Rash
- Synovitis
- Systemic Sclerosis
- Thrombocytopenia
- Toxic Epidermal Necrolysis
- Tuberculosis, Extrapulmonary
- Tuberculous Meningitis
- Ulcerative Colitis, Active
- Uveitis, Posterior
Ubrelvy
A total of 218 drugs are known to interact with Ubrelvy.
- Ubrelvy is in the drug class CGRP inhibitors.
- Ubrelvy is used to treat Migraine.
Drug and food interactions
ubrogepant food
Applies to: Ubrelvy (ubrogepant)
ADJUST DOSE: Grapefruit and grapefruit juice may increase the plasma concentrations of ubrogepant. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit. Inhibition of hepatic CYP450 3A4 may also contribute. The interaction has not been studied with grapefruit but has been reported for other CYP450 3A4 inhibitors. When ubrogepant was administered with the moderate CYP450 3A4 inhibitor verapamil during in vivo studies, ubrogepant peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 2.8- and 3.5-fold, respectively. In general, the effect of grapefruit juice is concentration-, dose- and preparation-dependent, and can vary widely among brands. Certain preparations of grapefruit juice (e.g., high dose, double strength) have sometimes demonstrated potent inhibition of CYP450 3A4, while other preparations (e.g., low dose, single strength) have typically demonstrated moderate inhibition.
When administered with a high-fat meal, ubrogepant time to maximum plasma concentration (Tmax) was delayed by 2 hours, which resulted in a 22% decrease in Cmax and no change in AUC. Ubrogepant was administered without regard to food in clinical efficacy studies.
MANAGEMENT: Ubrogepant may be administered with or without food. Per the manufacturer, when coadministered with grapefruit or grapefruit juice, the initial ubrogepant dose should be 50 mg, and if needed, a second ubrogepant dose should be avoided within 24 hours of the initial dose.
References
- (2019) "Product Information. Ubrelvy (ubrogepant)." Allergan Inc
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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