Drug Interactions between prednisone and Symproic
This report displays the potential drug interactions for the following 2 drugs:
- prednisone
- Symproic (naldemedine)
Interactions between your drugs
No interactions were found between prednisone and Symproic. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
prednisone
A total of 588 drugs are known to interact with prednisone.
- Prednisone is in the drug class glucocorticoids.
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Prednisone is used to treat the following conditions:
- Acute Lymphocytic Leukemia
- Adrenocortical Insufficiency
- Adrenogenital Syndrome
- Allergic Reactions
- Allergic Rhinitis
- Allergies
- Amyloidosis
- Ankylosing Spondylitis
- Aspiration Pneumonia
- Asthma
- Atopic Dermatitis
- Autoimmune Hemolytic Anemia
- Berylliosis
- Bullous Pemphigoid
- Bursitis
- Chorioretinitis
- Cluster Headaches
- Cogan's Syndrome
- Conjunctivitis, Allergic
- COPD
- Corneal Ulcer
- Crohn's Disease, Active
- Dermatitis Herpetiformis
- Dermatomyositis
- Diffuse Large B-Cell Lymphoma
- Eczema
- Epicondylitis, Tennis Elbow
- Erythroblastopenia
- Fibromyalgia
- Food Allergies
- Giant Cell Arteritis
- Gouty Arthritis
- Graft-versus-host disease
- Herpes Zoster
- Herpes Zoster Iridocyclitis
- Hypercalcemia of Malignancy
- Immune Thrombocytopenia
- Immunosuppression
- Inflammatory Bowel Disease
- Inflammatory Conditions
- Interstitial Lung Disease
- Iridocyclitis
- Iritis
- Juvenile Rheumatoid Arthritis
- Keratitis
- Leukemia
- Lichen Planopilaris
- Lichen Planus
- Lichen Sclerosus
- Loeffler's Syndrome
- Lupus
- Lupus Nephritis
- Lymphoma
- Mixed Connective Tissue Disease
- Multiple Sclerosis
- Mycosis Fungoides
- Nephrotic Syndrome
- Neurosarcoidosis
- Optic Neuritis
- Osteoarthritis
- Pemphigoid
- Pemphigus
- Pharyngitis
- Polymyalgia Rheumatica
- Polymyositis/Dermatomyositis
- Psoriasis
- Psoriatic Arthritis
- Ramsay Hunt Syndrome
- Rheumatoid Arthritis
- Sarcoidosis
- Scleroderma
- Seborrheic Dermatitis
- Sinusitis
- Skin Rash
- Synovitis
- Systemic Sclerosis
- Thrombocytopenia
- Toxic Epidermal Necrolysis
- Tuberculosis, Extrapulmonary
- Tuberculous Meningitis
- Ulcerative Colitis, Active
- Uveitis, Posterior
Symproic
A total of 167 drugs are known to interact with Symproic.
- Symproic is in the drug class peripheral opioid receptor antagonists.
- Symproic is used to treat Opioid-Induced Constipation.
Drug and food interactions
naldemedine food
Applies to: Symproic (naldemedine)
GENERALLY AVOID: Grapefruit juice may increase the plasma concentrations of naldemedine. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit. In pharmacokinetic studies, naldemedine systemic exposure (AUC) was increased approximately 90% by the moderate CYP450 3A4 inhibitor fluconazole and nearly 200% by the potent inhibitor itraconazole. The interaction has not been studied with grapefruit juice. In general, the effect of grapefruit juice is concentration-, dose- and preparation-dependent, and can vary widely among brands. Certain preparations of grapefruit juice (e.g., high dose, double strength) have sometimes demonstrated potent inhibition of CYP450 3A4, while other preparations (e.g., low dose, single strength) have typically demonstrated moderate inhibition. Increased exposure to naldemedine may precipitate opioid withdrawal symptoms such as hyperhidrosis, lacrimation, rhinorrhea, chills, diarrhea, abdominal pain, anxiety, insomnia, irritability, restlessness, and yawning.
Food does not significantly affect the overall bioavailability of naldemedine. When administered with a high-fat meal, the rate of naldemedine absorption was decreased, but not the extent. Specifically, naldemedine peak plasma concentration (Cmax) was decreased by approximately 35% and time to achieve Cmax was delayed from 0.75 hours in the fasted state to 2.5 hours in the fed state, while naldemedine AUC was not significantly changed.
MANAGEMENT: Naldemedine may be taken with or without food. Patients should avoid consumption of grapefruit and grapefruit juice during treatment with naldemedine.
References
- (2017) "Product Information. Symproic (naldemedine)." Shionogi USA Inc
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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