Opsynvi Drug Interactions
Currently displaying a list of 380 drugs known to interact with Opsynvi (macitentan / tadalafil).
- 62 major drug interactions
- 222 moderate drug interactions
- 96 minor drug interactions
Medications known to interact with Opsynvi
Note: Showing generic names only.
A
- abametapir topical
- acebutolol
- acetazolamide
- adagrasib
- adalimumab
- aldesleukin
- alefacept
- alfuzosin
- aliskiren
- alprostadil
- ambrisentan
- amifostine
- amiloride
- aminoglutethimide
- amiodarone
- amlodipine
- amobarbital
- amprenavir
- amyl nitrite
- anakinra
- apalutamide
- apomorphine
- apraclonidine ophthalmic
- aprepitant
- aprocitentan
- arginine
- armodafinil
- asciminib
- ashwaganda
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- atazanavir
- atenolol
- avacopan
- avanafil
- azilsartan medoxomil
B
- bedaquiline
- belzutifan
- benazepril
- bendroflumethiazide
- benzthiazide
- bepridil
- berotralstat
- betaxolol
- bexagliflozin
- bexarotene
- bicalutamide
- bimekizumab
- bisoprolol
- black cohosh
- boceprevir
- bosentan
- brentuximab
- brigatinib
- brimonidine ophthalmic
- brimonidine topical
- brodalumab
- bumetanide
- butabarbital
- butalbital
C
- calaspargase pegol
- canagliflozin
- canakinumab
- candesartan
- cannabidiol
- capivasertib
- captopril
- carbamazepine
- carteolol
- carvedilol
- cenobamate
- ceritinib
- chloramphenicol
- chlorothiazide
- chlorthalidone
- cimetidine
- ciprofloxacin
- citrulline
- clarithromycin
- clevidipine
- clofarabine
- clofazimine
- clonidine
- clotrimazole
- cobicistat
- conivaptan
- crizotinib
- cyclandelate
- cyclosporine
D
- dabrafenib
- daclizumab
- danazol
- dapagliflozin
- daridorexant
- darunavir
- dasatinib
- deferasirox
- delavirdine
- deserpidine
- dexamethasone
- diazoxide
- dichlorphenamide
- diltiazem
- doxazosin
- dronedarone
- duvelisib
E
- echinacea
- efavirenz
- elafibranor
- elagolix
- emapalumab
- empagliflozin
- enalapril
- enalaprilat
- encorafenib
- entrectinib
- enzalutamide
- epirubicin
- eplerenone
- epoprostenol
- eprosartan
- erdafitinib
- ertugliflozin
- erythromycin
- eslicarbazepine
- esmolol
- ethacrynic acid
- ethanol
- ethaverine
- etranacogene dezaparvovec
- etravirine
F
- fedratinib
- felbamate
- felodipine
- fenfluramine
- fenofibrate
- fenofibric acid
- fenoldopam
- fexinidazole
- fidanacogene elaparvovec
- finerenone
- fluconazole
- fluvoxamine
- fosamprenavir
- fosaprepitant
- fosinopril
- fosphenytoin
- fostamatinib
- furazolidone
- furosemide
G
- gemfibrozil
- givinostat
- glofitamab
- glycerol phenylbutyrate
- goldenseal
- golimumab
- grepafloxacin
- griseofulvin
- guanabenz
- guanadrel
- guanethidine
- guanfacine
- guselkumab
H
I
- idelalisib
- iloprost
- imatinib
- indapamide
- indinavir
- infliximab
- interferon beta-1a
- interferon beta-1b
- iptacopan
- irbesartan
- isavuconazonium
- isocarboxazid
- isoniazid
- isosorbide
- isosorbide dinitrate
- isosorbide mononitrate
- isoxsuprine
- isradipine
- itraconazole
- ivacaftor
- ivosidenib
K
L
- labetalol
- landiolol
- lapatinib
- larotrectinib
- lazertinib
- lefamulin
- leflunomide
- lenacapavir
- lesinurad
- letermovir
- levamlodipine
- levodopa
- levoketoconazole
- linezolid
- lisinopril
- lofexidine
- lomitapide
- lonafarnib
- lonapegsomatropin
- lorcaserin
- lorlatinib
- losartan
M
- maraviroc
- mavacamten
- mavorixafor
- mecamylamine
- mephobarbital
- methazolamide
- methotrexate
- methyclothiazide
- methyldopa
- metolazone
- metoprolol
- metreleptin
- mibefradil
- miconazole
- mifepristone
- minoxidil
- minoxidil topical
- mipomersen
- mitapivat
- mitotane
- mobocertinib
- modafinil
- moexipril
N
- nadolol
- nafcillin
- naltrexone
- nebivolol
- nefazodone
- nelfinavir
- nemolizumab
- nesiritide
- nevirapine
- nicardipine
- nifedipine
- nilotinib
- nimodipine
- nirogacestat
- nisoldipine
- nitisinone
- nitroglycerin
- nitroprusside
O
P
- pacritinib
- palbociclib
- papaverine
- pazopanib
- pegaspargase
- peginterferon beta-1a
- penbutolol
- pentobarbital
- pentoxifylline
- perindopril
- pexidartinib
- phenelzine
- phenobarbital
- phenoxybenzamine
- phentolamine
- phenylbutazone
- phenytoin
- pindolol
- pirtobrutinib
- pitolisant
- polythiazide
- posaconazole
- pralsetinib
- prazosin
- primidone
- procarbazine
- propranolol
Q
R
- ramipril
- ranolazine
- rasagiline
- rauwolfia serpentina
- remdesivir
- repotrectinib
- reserpine
- ribociclib
- rifabutin
- rifampin
- rifapentine
- rilonacept
- riociguat
- ritlecitinib
- ritonavir
- rucaparib
- rufinamide
S
- safinamide
- sapropterin
- saquinavir
- sarilumab
- satralizumab
- secobarbital
- secukinumab
- selegiline
- selexipag
- selpercatinib
- sildenafil
- silodosin
- siltuximab
- simeprevir
- sodium nitrite
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- sotagliflozin
- sotalol
- sotorasib
- sparsentan
- spironolactone
- st. john's wort
- stiripentol
- sulfinpyrazone
- suvorexant
- suzetrigine
T
- tamsulosin
- taurine
- tazemetostat
- tecovirimat
- telaprevir
- telithromycin
- telmisartan
- telotristat
- terazosin
- teriflunomide
- thioguanine
- ticagrelor
- timolol
- tipranavir
- tocilizumab
- tolazoline
- torsemide
- tovorafenib
- trabectedin
- trandolapril
- tranylcypromine
- treosulfan
- treprostinil
- triamterene
- trichlormethiazide
- trimethaphan camsylate
- trofinetide
- troglitazone
- troleandomycin
- tucatinib
U
V
- vadadustat
- valoctocogene roxaparvovec
- valsartan
- vardenafil
- vemurafenib
- verapamil
- vericiguat
- verteporfin
- viloxazine
- vorasidenib
- voriconazole
- vosoritide
- voxelotor
Y
Z
Opsynvi alcohol/food interactions
There is 1 alcohol/food interaction with Opsynvi (macitentan / tadalafil).
Opsynvi disease interactions
There are 13 disease interactions with Opsynvi (macitentan / tadalafil) which include:
- hepatotoxicity/liver impairment
- cardiovascular disease
- renal dysfunction
- pulmonary disease
- anemia
- fluid retention
- priapism
- alcoholism
- hearing loss
- liver disease
- retinitis pigmentosa
- seizure disorders
- Tadalafil-visual disorders
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More about Opsynvi (macitentan / tadalafil)
- Opsynvi consumer information
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- Compare alternatives
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- Drug images
- Side effects
- Dosage information
- During pregnancy
- FDA approval history
- Drug class: agents for pulmonary hypertension
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
