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Ivacaftor / tezacaftor Drug Interactions

A total of 429 drugs are known to interact with ivacaftor / tezacaftor.

  • 87 major drug interactions
  • 325 moderate drug interactions
  • 17 minor drug interactions

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Type in a drug name to check for interactions with ivacaftor / tezacaftor.

Medications known to interact with ivacaftor / tezacaftor

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    • edoxaban (Savaysa)
    • efavirenz (Sustiva)
    • efavirenz / emtricitabine / tenofovir (Atripla)
    • efavirenz / lamivudine / tenofovir (Symfi, Symfi Lo)
    • elagolix (Orilissa)
    • elbasvir / grazoprevir (Zepatier)
    • eletriptan (Relpax)
    • eliglustat (Cerdelga)
    • eluxadoline (Viberzi)
    • emtricitabine / lopinavir / ritonavir / tenofovir (AccessPak for HIV PEP Expanded with Kaletra)
    • emtricitabine / nelfinavir / tenofovir (AccessPak for HIV PEP Expanded with Viracept)
    • enalapril / felodipine (Lexxel)
    • encorafenib (Braftovi)
    • enzalutamide (Xtandi)
    • ephedrine / phenobarbital / potassium iodide / theophylline (Quadrinal)
    • ephedrine / phenobarbital / theophylline (Tedrigen, Theodrine)
    • epinephrine / lidocaine (Xylocaine with Epinephrine, Xylocaine-MPF-Epinephrine, Lignospan, Octocaine 100, Xylocaine HCl with Epinephrine, Xylocaine with Epinephrine Dental Cartridges, Lignospan Forte, Xylocaine Dental, LidoSite)
    • epirubicin (Ellence, Pharmorubicin PFS, Pharmorubicin RDF)
    • eplerenone (Inspra)
    • ergonovine (Ergotrate, Ergotrate Maleate)
    • ergotamine (Ergomar)
    • erlotinib (Tarceva)
    • erythromycin (Erythrocin, E-Mycin, EryPed, Ery-Tab, Ilosone, Eryc, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, Robimycin, PCE Dispertab, Wyamycin S, E.E.S. Granules, E.E.S.-200, E.E.S.-400, E.E.S.-400 Filmtab, Erythrocot, MY-E)
    • erythromycin / sulfisoxazole (Pediazole, Eryzole, Sulfimycin, E S P)
    • escitalopram (Lexapro)
    • eslicarbazepine (Aptiom)
    • estazolam (Prosom)
    • estradiol (Estrace, Estradiol Patch, Climara, Minivelle, Vivelle-Dot, Estrogel, Vivelle, Estrogen Patches, Femring, Divigel, Evamist, Delestrogen, Elestrin, Alora, Estraderm, Estradot, Elleste Solo, Estrofem, Oestrogel, Menostar, Valergen, Evorel, Progynova, Primogyn Depot, Oestradiol Implants, Estradiol G GAM, Estreva, Depo-Estradiol, Estra-C, Oesclim, Menaval-20, Oestrogel Pump-Pack, Aerodiol, Sandrena, Fematrix, FemTab, Estrasorb, Femtran, Climodien, Organon Oestradiol, Estra Pellets, Depogen, Dep Gynogen, Gynogen LA 20, Dioval 40, Dioval XX, Duragen, Estra-V 40, Estro-Cyp, Gynodiol, Estro-Span 40, Medidiol 10, Dura-Estrin, Fempatch, Esclim, Estragyn LA 5, Clinagen LA 40, Estro-LA, Estradot 37.5, Estradot 50, Estradot 75, Estradot 100, Dermestril, FemSeven, Progynova TS, Zumenon, Adgyn Estro, FemSeven Sequi Phase I, Menorest Patch, Nuvelle TS Phase I, Climaval, Bedol, Delidose, Dermestril Septem, Estrapatch, Femsept, Menorest, Oestrodose, Oromone, Provames, Systen, Thais, Thaissept, Dotti, Femtrace)
    • estradiol topical (Vagifem, Yuvafem, Estrace Vaginal Cream, Estring, Imvexxy)
    • estradiol / levonorgestrel (Climara Pro)
    • estradiol / medroxyprogesterone (Lunelle)
    • estradiol / norethindrone (CombiPatch, Activella, Mimvey, Amabelz, Lopreeza, Mimvey Lo, Ena)
    • estradiol / norethindrone topical
    • estradiol / norgestimate (Prefest, Ortho-Prefest)
    • estradiol / progesterone (Bijuva)
    • estradiol / testosterone (Depo-Testadiol, Depotestogen, Dep Androgyn, Delatestadiol, Estra-Testrin, Valertest No 1, Duo-Cyp, Dura-Dumone, Duratestrin)
    • estrone (Estrone AQ, Kestrone 5, Estragyn 5, Aquest, Estro-A)
    • estropipate (Ogen, Ogen 0.625, Ortho-Est, Ogen 1.25, Ogen 2.5)
    • estropipate topical (Ogen Vaginal Cream)
    • eszopiclone (Lunesta)
    • ethinyl estradiol (Estinyl)
    • ethinyl estradiol / ethynodiol (Kelnor 1/35, Zovia 1/35E, Zovia 1/50E, Demulen 1/35, Demulen, Demulen 1/50, Kelnor 1/50, Lo-Malmorede, Malmorede)
    • ethinyl estradiol / etonogestrel (NuvaRing)
    • ethinyl estradiol / folic acid / levonorgestrel (FaLessa Kit)
    • ethinyl estradiol / levonorgestrel (Aviane, Alesse, Seasonique, Lutera, Seasonale, Levora, Orsythia, Portia, Altavera, Amethyst, Amethia, Vienva, Trivora, Lessina, Sronyx, Aubra, Jolessa, Daysee, Camrese, Introvale, Ashlyna, Larissia, Kurvelo, Alesse-28, Falmina, Levlen, Lillow, Balcoltra, LoSeasonique, Lybrel, Setlakin, Nordette, Triphasil, Chateal, Enpresse, Quasense, Simpesse, Levonest, Afirmelle, Amethia Lo, Chateal EQ, Marlissa, Rivelsa, Ayuna, Fayosim, Jaimiess, Alesse-21, Preven EC, CamreseLo, Myzilra, Quartette, Lo Simpesse, Cerinta, Nordette-21, Elifemme, Nordette-28, Tri-Levlen, Triphasil-21, Triphasil-28, Sylevia, Levlite, Triquilar 21, Triquilar 28, Min-Ovral 21, Min-Ovral 28, Delyla, Iclevia, Aubra EQ)
    • ethinyl estradiol / norelgestromin (Xulane, Ortho Evra)
    • ethinyl estradiol / norethindrone (Lo Loestrin Fe, Junel Fe 1/20, Necon 1/35, Taytulla, Microgestin Fe 1/20, Minastrin 24 Fe, Estrostep Fe, Loestrin 21 1/20, Loestrin Fe 1/20, Blisovi 24 Fe, Loestrin 24 Fe, Loestrin Fe 1.5/30, Nortrel 1/35, Junel Fe 1.5/30, Junel 1.5/30, Blisovi Fe 1/20, Junel Fe 24, Mibelas 24 Fe, Jinteli, Microgestin 1/20, Microgestin 1.5/30, Larin Fe 1/20, Melodetta 24 Fe, Blisovi Fe 1.5/30, Pirmella 1/35, Cyclafem 1/35, femhrt, Junel 1/20, Wymzya Fe, Tarina Fe 1/20, Microgestin Fe 1.5/30, Fyavolv, Alyacen 1/35, Layolis Fe, Ortho-Novum 7/7/7, Ortho-Novum 1/35, Necon 0.5/35, Necon 10/11, Necon 7/7/7, Nortrel 0.5/35, Balziva, Femcon Fe, Tri-Legest Fe, Brevicon, Gildess Fe 1/20, Nortrel 7/7/7, Aranelle, Kaitlib Fe, Tri-Legest, Tilia Fe, Dasetta, Vyfemla, Larin 24 Fe, Jevantique, Hailey 24 Fe, Pirmella 7/7/7, Modicon, Ovcon 35, Norinyl 1+35, Loestrin 21 1.5/30, Ovcon 50, Jenest, Ortho-Novum 10/11, Leena, Zenchent Fe, Zenchent, Nylia 1/35, Aurovela Fe 1.5/30, Tarina 24 Fe, Briellyn, Alyacen 7/7/7, Larin Fe 1.5/30, Gildess 1/20, Microgestin 24 Fe, Larin 1.5/30, Larin 1/20, Generess Fe, Gildess 24 Fe, Hailey Fe 1/20, Wera, Cyclafem 7/7/7, Genora 0.5/35, Nelova 0.5/35, Gildess Fe 1.5/30, Genora 1/35, Norethin 1/35 E, Nelova 10/11, Nelova 1/35, Tri-Norinyl, Ovcon 35 Fe, Nylia 7/7/7, Cyonanz, Aurovela 24 Fe, Aurovela Fe 1/20, Aurovela 1/20, Leribane, Aurovela 1.5/30, Cyclafem 0.5/35, Lo Minastrin Fe, Gildagia, Lomedia 24 Fe, Dasetta 7/7/7, Philith, Dasetta 1/35, Zeosa, Hailey 1.5/30, Hailey Fe 1.5/30, Nexesta Fe, Gildess 1.5/30, Jevantique Lo)
    • ethinyl estradiol / norgestimate (Sprintec, Ortho Tri-Cyclen, Tri-Sprintec, TriNessa, Estarylla, Ortho Tri-Cyclen Lo, Mononessa, Tri-Lo-Sprintec, Ortho Cyclen, Femynor, Mono-Linyah, TriNessa Lo, Tri-Lo-Estarylla, Tri-Estarylla, Tri-Linyah, Tri-Lo-Marzia, VyLibra, Tri-Previfem, Previfem, Tri Femynor, Mili, Tri-Vylibra Lo, Tri-VyLibra, Tri-Lo-Mili, Tri-Mili)
    • ethinyl estradiol / norgestrel (Cryselle, Lo/Ovral, Elinest, Ovral, Low-Ogestrel-28, Ogestrel 0.5/50, Lo/Ovral-28, Ovral-28, Ovral-21)
    • ethinyl estradiol / segesterone (Annovera)
    • ethosuximide (Zarontin)
    • etonogestrel (Nexplanon, Implanon)
    • etoposide (Toposar, VePesid, Etopophos)
    • etravirine (Intelence)
    • everolimus (Afinitor, Zortress, Afinitor Disperz)
    • ezetimibe / simvastatin (Vytorin)
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    • lapatinib (Tykerb)
    • larotrectinib (Vitrakvi)
    • leflunomide (Arava)
    • letermovir (Prevymis)
    • letrozole (Femara)
    • letrozole / ribociclib (Kisqali Femara Co-Pack)
    • levonorgestrel (Mirena, Plan B, Plan B One-Step, Skyla, Kyleena, Liletta, Take Action, New Day, Aftera, My Way, Preventeza, EContra One-Step, Morning After, AfterPill, My Choice, Next Choice One Dose, Her Style, Option 2, Athentia Next, Norplant System, React, EContra EZ, Fallback Solo, Next Choice, Opcicon One-Step)
    • lidocaine (Xylocaine-MPF, Xylocaine Dental Cartridges, Nervocaine, Xylocaine HCl, Lidoject 1, Lidoject 2, Xylocaine Duo-Trach Kit, Xylocaine HCl For Spinal, L-Caine, Dilocaine, Truxacaine, UAD Caine, Anestacaine, DentiPatch)
    • lidocaine / oxytetracycline (Terramycin IM)
    • lidocaine / potassium chloride
    • lidocaine / sodium bicarbonate
    • lomitapide (Juxtapid)
    • loperamide (Imodium, Imodium A-D, Anti-Diarrheal, Pepto Diarrhea Control, Diamode, Kaopectate II, Neo-Diaral, Imotil, Kao-Paverin, Diar-Aid, Up and Up Anti-Diarrheal Solution, Kaopectate 1-D, A-D Anti-Diarrheal)
    • loperamide / simethicone (Anti-Diarrheal + Anti-Gas, Imodium Multi-Symptom Relief)
    • lopinavir / ritonavir (Kaletra)
    • loratadine (Claritin, Alavert, Claritin 24 Hour Allergy, Loratadine Reditab, Allergy Relief 24 Hour, Claritin Reditabs, Allergy Relief Tablets, Wal-itin, Children's Claritin Allergy, Children's Allergy Relief 24 Hour, Vicks QlearQuil All Day & All Night 24 Hour Allergy Relief, Help I Have Allergies, ohm Allergy Relief, Clear-Atadine, Claritin Hives Relief, Dimetapp Children's ND Non-Drowsy Allergy, Clear-Atadine Children's, Bactimicina Allergy, Tavist ND)
    • loratadine / pseudoephedrine (Claritin-D, Loratadine-D 24 Hour, Loratadine-D 12 Hour, Claritin-D 24 Hour, Claritin-D 12 Hour, AllerClear D-24 Hour, Clear-Atadine-D, Alavert D-12 Hour Allergy and Sinus, Allergy Relief D12, Leader Allergy Relief D-24, Allergy & Congestion Relief, Allergy Relief D 24 Hour)
    • lorlatinib (Lorbrena)
    • lovastatin (Mevacor, Altoprev, Altocor)
    • lovastatin / niacin (Advicor)
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    • quinidine (Quinora, Quinidex Extentabs, Cardioquin, Quinaglute Dura-Tabs, Quin-Release, Quin-G)
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    Ivacaftor / tezacaftor alcohol/food interactions

    There is 1 alcohol/food interaction with ivacaftor / tezacaftor

    Ivacaftor / tezacaftor disease interactions

    There are 3 disease interactions with ivacaftor / tezacaftor which include:

    Drug Interaction Classification

    These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
    Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
    Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
    Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
    Unknown No interaction information available.

    Further information

    Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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