Cobimetinib Drug Interactions
Currently displaying a list of 399 drugs known to interact with cobimetinib.
- 124 major drug interactions
- 275 moderate drug interactions
Medications known to interact with cobimetinib
Note: Showing generic names only.
- abametapir topical
- abiraterone
- abrocitinib
- adagrasib
- adalimumab
- adenovirus vaccine
- alefacept
- alemtuzumab
- alpelisib
- aminoglutethimide
- aminolevulinic acid
- aminolevulinic acid topical
- amiodarone
- amlodipine
- amobarbital
- amprenavir
- anakinra
- anthrax vaccine adsorbed
- apalutamide
- aprepitant
- armodafinil
- asciminib
- atazanavir
- atezolizumab
- avacopan
- avelumab
- azathioprine
- baricitinib
- bcg
- bcg vaccine
- bedaquiline
- belzutifan
- bepridil
- berotralstat
- bexarotene
- bicalutamide
- bifidobacterium infantis
- bifidobacterium longum
- black cohosh
- boceprevir
- bosentan
- brentuximab
- brewer's yeast
- brigatinib
- butabarbital
- butalbital
- cabozantinib
- canakinumab
- candida albicans extract
- cannabidiol
- capivasertib
- capmatinib
- carbamazepine
- cemiplimab
- cenobamate
- ceritinib
- certolizumab
- chikungunya vaccine, live (cvx 317)
- chikungunya vaccine, recombinant (cvx 329)
- chloramphenicol
- chloramphenicol ophthalmic
- chloramphenicol otic
- chloroquine
- cholera vaccine
- cholera vaccine, live
- cimetidine
- ciprofloxacin
- cladribine
- clarithromycin
- clofarabine
- clofazimine
- clotrimazole
- cobicistat
- coccidioidin skin test
- conivaptan
- cosibelimab
- COVID-19 mRNA (Moderna) vaccine
- COVID-19 mRNA (Pfizer) vaccine
- crizotinib
- cyclosporine
- dabrafenib
- daclatasvir
- daclizumab
- danazol
- danicopan
- daridorexant
- darunavir
- dasatinib
- deferasirox
- delavirdine
- dengue vaccine
- denosumab
- deucravacitinib
- dexamethasone
- diltiazem
- dimethyl fumarate
- diroximel fumarate
- dostarlimab
- dronedarone
- durvalumab
- duvelisib
- echinacea
- efalizumab
- efavirenz
- elacestrant
- elafibranor
- elagolix
- eliglustat
- encorafenib
- entrectinib
- enzalutamide
- epirubicin
- erdafitinib
- erythromycin
- eslicarbazepine
- etanercept
- etrasimod
- etravirine
- ezogabine
- fedratinib
- felbamate
- felodipine
- fenfluramine
- fexinidazole
- fidaxomicin
- fingolimod
- flibanserin
- fluconazole
- fluvoxamine
- fosamprenavir
- fosaprepitant
- fosphenytoin
- fostamatinib
- futibatinib
- haemophilus b conjugate (hboc) vaccine
- haemophilus b conjugate (prp-omp) vaccine
- haemophilus b conjugate (prp-t) vaccine
- hepatitis a adult vaccine
- hepatitis a pediatric vaccine
- hepatitis b adult vaccine
- hepatitis b pediatric vaccine
- histoplasmin
- human papillomavirus vaccine
- hydroxychloroquine
- idelalisib
- imatinib
- indinavir
- infliximab
- influenza virus vaccine, h1n1, inactivated
- influenza virus vaccine, h1n1, live
- influenza virus vaccine, h5n1
- influenza virus vaccine, inactivated
- influenza virus vaccine, live
- interferon beta-1a
- interferon beta-1b
- ipilimumab
- iptacopan
- isavuconazonium
- isoniazid
- istradefylline
- itraconazole
- ivacaftor
- ivosidenib
- lactobacillus acidophilus
- lactobacillus reuteri
- lactobacillus rhamnosus
- lactobacillus rhamnosus gg
- lapatinib
- larotrectinib
- lasmiditan
- lazertinib
- lefamulin
- leflunomide
- lenacapavir
- letermovir
- levacetylleucine
- levamlodipine
- levoketoconazole
- lomitapide
- lonafarnib
- lonapegsomatropin
- loncastuximab tesirine
- lorlatinib
- lyme disease vaccine
- mavacamten
- mavorixafor
- measles virus vaccine
- meningococcal conjugate vaccine
- meningococcal group acwy conjugate-group b vaccine (cvx 316)
- meningococcal group B vaccine
- meningococcal polysaccharide vaccine
- mephobarbital
- methotrexate
- methoxsalen
- methyl aminolevulinate topical
- metreleptin
- mibefradil
- miconazole
- midostaurin
- mifepristone
- mipomersen
- mitapivat
- mitotane
- mixed respiratory vaccine
- mobocertinib
- modafinil
- monomethyl fumarate
- mumps skin test antigen
- mumps virus vaccine
- nadofaragene firadenovec
- nafcillin
- naltrexone
- natalizumab
- nefazodone
- nelfinavir
- neratinib
- nevirapine
- nifedipine
- nilotinib
- niraparib
- nirogacestat
- nivolumab
- pacritinib
- palbociclib
- palifermin
- pazopanib
- peginterferon beta-1a
- pembrolizumab
- pemigatinib
- pentobarbital
- pertussis, acellular
- pexidartinib
- phenobarbital
- phenylbutazone
- phenytoin
- pirtobrutinib
- plague vaccine
- pneumococcal 13-valent vaccine
- pneumococcal 15-valent conjugate vaccine
- pneumococcal 20-valent conjugate vaccine
- pneumococcal 21-valent conjugate vaccine
- pneumococcal 23-polyvalent vaccine
- pneumococcal 7-valent vaccine
- poliovirus vaccine, inactivated
- poliovirus vaccine, live, trivalent
- ponatinib
- ponesimod
- porfimer
- posaconazole
- pralsetinib
- pretomanid
- primidone
- rabies vaccine, human diploid cell
- rabies vaccine, purified chick embryo cell
- radium 223 dichloride
- ranolazine
- remdesivir
- repotrectinib
- retifanlimab
- ribociclib
- rifabutin
- rifampin
- rifapentine
- rilonacept
- ripretinib
- risdiplam
- ritlecitinib
- ritonavir
- roflumilast
- rolapitant
- ropeginterferon alfa-2b
- rotavirus vaccine
- rsv vaccine pref3, recombinant
- rsv vaccine, mrna
- rsv vaccine, pref a-pref b, recombinant
- rubella virus vaccine
- rucaparib
- rufinamide
- saccharomyces boulardii lyo
- samarium sm 153 lexidronam
- saquinavir
- sarecycline
- sars-cov-2 (covid-19) ad26 vaccine, recombinant
- sars-cov-2 (covid-19) chadox1 vaccine, recombinant
- sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 308)
- sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 309)
- sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 310)
- sars-cov-2 (covid-19) nvx-cov2373 vaccine, recombinant
- sars-cov-2 (covid-19) rs-nanoparticle vaccine, recombinant
- sars-cov-2 mrna (tozinameran 5y-11y) vaccine
- sars-cov-2 mrna (tozinameran 6m-4y) vaccine
- sars-cov-2 mrna (tozinameran-tris-sucrose) vaccine
- sars-cov-2 mrna (tozinameran) vaccine
- sars-cov-2 mrna-1273 (6m-5y) vaccine
- sars-cov-2 mrna-1273 (6y-11y) vaccine
- sars-cov-2 mrna-1273 (booster only) vaccine
- sars-cov-2 nvx-cov2373 vaccine, recomb (cvx 313)
- sars-cov-2 pres dtm (booster only) vaccine, recombinant
- secobarbital
- selpercatinib
- simeprevir
- siponimod
- sipuleucel-T
- skin test antigens, multiple
- smallpox and mpox vaccine
- smallpox vaccine
- sodium phosphate p32
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- sotorasib
- sparsentan
- spironolactone
- st. john's wort
- staphage lysate (spl)
- stiripentol
- streptococcus salivarius
- strontium-89 chloride
- sulfinpyrazone
- suvorexant
- suzetrigine
- tacrolimus
- talimogene laherparepvec
- tamoxifen
- tazemetostat
- tecovirimat
- telaprevir
- telithromycin
- telotristat
- tepotinib
- teriflunomide
- tetanus toxoid
- thioguanine
- ticagrelor
- tick-borne encephalitis (inactivated) pediatric vaccine
- tick-borne encephalitis (inactivated) vaccine
- tislelizumab
- tofacitinib
- tolvaptan
- topotecan
- toripalimab
- tovorafenib
- trabectedin
- tremelimumab
- treosulfan
- trichophyton skin test
- trofinetide
- troglitazone
- troleandomycin
- tuberculin purified protein derivative
- tucatinib
- typhoid vaccine, inactivated
- typhoid vaccine, live
- vadadustat
- valganciclovir
- vandetanib
- varicella virus vaccine
- venetoclax
- verapamil
- verteporfin
- vigabatrin
- viloxazine
- vimseltinib
- voclosporin
- vonoprazan
- vorasidenib
- voriconazole
- voxelotor
Cobimetinib alcohol/food interactions
There is 1 alcohol/food interaction with cobimetinib.
Cobimetinib disease interactions
There are 7 disease interactions with cobimetinib which include:
- cardiomyopathy
- hepatotoxicity
- ocular toxicities
- rhabdomyolysis
- lung toxicity
- liver dysfunction
- renal impairment
More about cobimetinib
- cobimetinib consumer information
- Check interactions
- Compare alternatives
- Side effects
- Dosage information
- During pregnancy
- Drug class: multikinase inhibitors
- Breastfeeding
- En español
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
See also:
Keytruda
Keytruda is used to treat multiple types of cancer such as melanoma, non-small cell lung cancer ...
Opdivo
Opdivo is used to treat many cancers, such as melanoma, non-small cell lung cancer, malignant ...
Ubrelvy
Ubrelvy (ubrogepant) tablets are used for the acute treatment of migraine. Includes Ubrelvy side ...
Yervoy
Yervoy (ipilimumab) is a cancer treatment used for lung cancer, melanoma, renal cell carcinoma ...
Mekinist
Mekinist is used to treat melanoma, non-small cell lung cancer, thyroid cancer, solid tumors, and ...
Braftovi
Braftovi is a targeted cancer treatment used in combination with Mektovi, mFOLFOX6, or Erbitux, to ...
Cotellic
Cotellic (cobimetinib) is used in combination with vemurafenib to treat advanced melanoma. Includes ...
Dacarbazine
Dacarbazine systemic is used for hodgkin's lymphoma, melanoma, melanoma, metastatic
Ipilimumab
ipilimumab (Yervoy) is an immunotherapy used for melanoma, renal cell carcinoma, non-small cell ...
Dabrafenib
Dabrafenib systemic is used for low-grade glioma, melanoma, metastatic, non small cell lung cancer ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.