Cobimetinib Drug Interactions
Currently displaying a list of 403 drugs known to interact with cobimetinib.
- 124 major drug interactions
- 279 moderate drug interactions
Medications known to interact with cobimetinib
Note: Showing generic names only.
A
- abametapir topical
- abiraterone
- abrocitinib
- adagrasib
- adalimumab
- adenovirus vaccine
- alefacept
- alemtuzumab
- alpelisib
- aminoglutethimide
- aminolevulinic acid
- aminolevulinic acid topical
- amiodarone
- amlodipine
- amobarbital
- amprenavir
- anakinra
- anthrax vaccine adsorbed
- apalutamide
- aprepitant
- armodafinil
- asciminib
- atazanavir
- atezolizumab
- avacopan
- avelumab
- azathioprine
B
- baricitinib
- bcg
- bcg vaccine
- bedaquiline
- belzutifan
- bepridil
- berotralstat
- bexarotene
- bicalutamide
- bifidobacterium infantis
- bifidobacterium longum
- black cohosh
- boceprevir
- bosentan
- brentuximab
- brewer's yeast
- brigatinib
- butabarbital
- butalbital
C
- cabozantinib
- canakinumab
- candida albicans extract
- cannabidiol
- capivasertib
- capmatinib
- carbamazepine
- cemiplimab
- cenobamate
- ceritinib
- certolizumab
- chikungunya vaccine, live (cvx 317)
- chikungunya vaccine, recombinant (cvx 329)
- chloramphenicol
- chloramphenicol ophthalmic
- chloramphenicol otic
- chloroquine
- cholera vaccine
- cholera vaccine, live
- cimetidine
- ciprofloxacin
- cladribine
- clarithromycin
- clofarabine
- clofazimine
- clotrimazole
- cobicistat
- coccidioidin skin test
- conivaptan
- cosibelimab
- COVID-19 mRNA (Moderna) vaccine
- COVID-19 mRNA (Pfizer) vaccine
- crizotinib
- cyclosporine
D
- dabrafenib
- daclatasvir
- daclizumab
- danazol
- danicopan
- daridorexant
- darunavir
- dasatinib
- deferasirox
- delavirdine
- dengue vaccine
- denosumab
- deucravacitinib
- dexamethasone
- diltiazem
- dimethyl fumarate
- diroximel fumarate
- dostarlimab
- dronedarone
- durvalumab
- duvelisib
E
- echinacea
- efalizumab
- efavirenz
- elacestrant
- elafibranor
- elagolix
- eliglustat
- encorafenib
- entrectinib
- enzalutamide
- epirubicin
- erdafitinib
- erythromycin
- eslicarbazepine
- etanercept
- etrasimod
- etravirine
- ezogabine
F
- fedratinib
- felbamate
- felodipine
- fenfluramine
- fexinidazole
- fidaxomicin
- fingolimod
- flibanserin
- fluconazole
- fluvoxamine
- fosamprenavir
- fosaprepitant
- fosphenytoin
- fostamatinib
- futibatinib
G
H
- haemophilus b conjugate (hboc) vaccine
- haemophilus b conjugate (prp-omp) vaccine
- haemophilus b conjugate (prp-t) vaccine
- hepatitis a adult vaccine
- hepatitis a pediatric vaccine
- hepatitis b adult vaccine
- hepatitis b pediatric vaccine
- histoplasmin
- human papillomavirus vaccine
- hydroxychloroquine
I
- idelalisib
- imatinib
- indinavir
- infliximab
- influenza virus vaccine, h1n1, inactivated
- influenza virus vaccine, h1n1, live
- influenza virus vaccine, h5n1
- influenza virus vaccine, inactivated
- influenza virus vaccine, live
- interferon beta-1a
- interferon beta-1b
- ipilimumab
- iptacopan
- isavuconazonium
- isoniazid
- istradefylline
- itraconazole
- ivacaftor
- ivosidenib
J
K
L
- lactobacillus acidophilus
- lactobacillus reuteri
- lactobacillus rhamnosus
- lactobacillus rhamnosus gg
- lapatinib
- larotrectinib
- lasmiditan
- lazertinib
- lefamulin
- leflunomide
- lenacapavir
- letermovir
- levacetylleucine
- levamlodipine
- levoketoconazole
- lomitapide
- lonafarnib
- lonapegsomatropin
- loncastuximab tesirine
- lorlatinib
- lyme disease vaccine
M
- maribavir
- mavacamten
- mavorixafor
- measles virus vaccine
- meningococcal conjugate vaccine
- meningococcal group acwy conjugate-group b vaccine (cvx 316)
- meningococcal group B vaccine
- meningococcal polysaccharide vaccine
- mephobarbital
- methotrexate
- methoxsalen
- methyl aminolevulinate topical
- metreleptin
- mibefradil
- miconazole
- midostaurin
- mifepristone
- mipomersen
- mitapivat
- mitotane
- mixed respiratory vaccine
- mobocertinib
- modafinil
- monomethyl fumarate
- mumps skin test antigen
- mumps virus vaccine
N
- nadofaragene firadenovec
- nafcillin
- naltrexone
- natalizumab
- nefazodone
- nelfinavir
- neratinib
- nevirapine
- nifedipine
- nilotinib
- niraparib
- nirogacestat
- nivolumab
O
P
- pacritinib
- palbociclib
- palifermin
- pazopanib
- peginterferon beta-1a
- pembrolizumab
- pemigatinib
- penpulimab
- pentobarbital
- pertussis, acellular
- pexidartinib
- phenobarbital
- phenylbutazone
- phenytoin
- pirtobrutinib
- plague vaccine
- pneumococcal 13-valent vaccine
- pneumococcal 15-valent conjugate vaccine
- pneumococcal 20-valent conjugate vaccine
- pneumococcal 21-valent conjugate vaccine
- pneumococcal 23-polyvalent vaccine
- pneumococcal 7-valent vaccine
- poliovirus vaccine, inactivated
- poliovirus vaccine, live, trivalent
- ponatinib
- ponesimod
- porfimer
- posaconazole
- pralsetinib
- pretomanid
- primidone
Q
R
- rabies vaccine, human diploid cell
- rabies vaccine, purified chick embryo cell
- radium 223 dichloride
- ranolazine
- remdesivir
- repotrectinib
- retifanlimab
- ribociclib
- rifabutin
- rifampin
- rifapentine
- rilonacept
- ripretinib
- risdiplam
- ritlecitinib
- ritonavir
- roflumilast
- rolapitant
- ropeginterferon alfa-2b
- rotavirus vaccine
- rsv vaccine pref3, recombinant
- rsv vaccine, mrna
- rsv vaccine, pref a-pref b, recombinant
- rubella virus vaccine
- rucaparib
- rufinamide
S
- saccharomyces boulardii lyo
- samarium sm 153 lexidronam
- saquinavir
- sarecycline
- sars-cov-2 (covid-19) ad26 vaccine, recombinant
- sars-cov-2 (covid-19) chadox1 vaccine, recombinant
- sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 308)
- sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 309)
- sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 310)
- sars-cov-2 (covid-19) nvx-cov2373 vaccine, recombinant
- sars-cov-2 (covid-19) nvx-cov2705 vaccine, adjuvanted
- sars-cov-2 (covid-19) rs-nanoparticle vaccine, recombinant
- sars-cov-2 mrna (tozinameran 5y-11y) vaccine
- sars-cov-2 mrna (tozinameran 6m-4y) vaccine
- sars-cov-2 mrna (tozinameran-tris-sucrose) vaccine
- sars-cov-2 mrna (tozinameran) vaccine
- sars-cov-2 mrna-1273 (6m-5y) vaccine
- sars-cov-2 mrna-1273 (6y-11y) vaccine
- sars-cov-2 mrna-1273 (booster only) vaccine
- sars-cov-2 nvx-cov2373 vaccine, recomb (cvx 313)
- sars-cov-2 pres dtm (booster only) vaccine, recombinant
- secobarbital
- selpercatinib
- simeprevir
- siponimod
- sipuleucel-T
- skin test antigens, multiple
- smallpox and mpox vaccine
- smallpox vaccine
- sodium phosphate p32
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- sotorasib
- sparsentan
- spironolactone
- st. john's wort
- staphage lysate (spl)
- stiripentol
- streptococcus salivarius
- strontium-89 chloride
- sulfinpyrazone
- suvorexant
- suzetrigine
T
- tacrolimus
- tacrolimus topical
- talimogene laherparepvec
- tamoxifen
- tazemetostat
- tecovirimat
- telaprevir
- telithromycin
- telotristat
- tepotinib
- teriflunomide
- tetanus toxoid
- thioguanine
- ticagrelor
- tick-borne encephalitis (inactivated) pediatric vaccine
- tick-borne encephalitis (inactivated) vaccine
- tislelizumab
- tofacitinib
- tolvaptan
- topotecan
- toripalimab
- tovorafenib
- trabectedin
- tremelimumab
- treosulfan
- trichophyton skin test
- trofinetide
- troglitazone
- troleandomycin
- tuberculin purified protein derivative
- tucatinib
- typhoid vaccine, inactivated
- typhoid vaccine, live
U
V
- vadadustat
- valganciclovir
- vandetanib
- varicella virus vaccine
- venetoclax
- verapamil
- verteporfin
- vigabatrin
- viloxazine
- vimseltinib
- voclosporin
- vonoprazan
- vorasidenib
- voriconazole
- voxelotor
Y
Z
Cobimetinib alcohol/food interactions
There is 1 alcohol/food interaction with cobimetinib.
Cobimetinib disease interactions
There are 7 disease interactions with cobimetinib which include:
- cardiomyopathy
- hepatotoxicity
- ocular toxicities
- rhabdomyolysis
- lung toxicity
- liver dysfunction
- renal impairment
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More about cobimetinib
- cobimetinib consumer information
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- Drug class: multikinase inhibitors
- Breastfeeding
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
