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Drug Interactions between cobimetinib and verteporfin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

verteporfin cobimetinib

Applies to: verteporfin and cobimetinib

Using verteporfin together with cobimetinib may cause an increase in photosensitivity reactions, which could cause your skin to burn when exposed to light. Check with your doctor to see if you should temporarily withhold any of your medications before and after treatment with verteporfin. You should avoid exposure of skin or eyes to sunlight or bright indoor lights (examination lamps, operating room lamps, tanning beds, lights at close proximity) for 5 days after treatment with verteporfin. If you must go outdoors in the daylight during this 5-day time frame it is important to protect your skin and eyes by wearing protective clothing and dark sunglasses, even if you cannot see the sun (e.G., cloudy day). Exposing your skin to normal indoor lighting is helpful as it will help your body get rid of verteporfin more quickly, so you do not need to stay inside in the dark. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

cobimetinib food

Applies to: cobimetinib

Grapefruit juice may increase the blood levels and effects of certain medications such as cobimetinib. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with cobimetinib. However, if you have been regularly consuming grapefruit or grapefruit juice with cobimetinib, do not alter the amounts of these products in your diet without first talking to your doctor or other healthcare professional. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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