Drug Interactions between black cohosh and cobimetinib

Talk to your doctor before using cobimetinib together with black cohosh. Products containing black cohosh have been reported to cause liver damage in rare cases, and taking it with other medications that can also affect the liver such as cobimetinib may increase that risk. You should avoid or limit the use of alcohol while being treated with these medications. Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.