Drug Interactions between Acetylsalicylic Acid and ampicillin
This report displays the potential drug interactions for the following 2 drugs:
- Acetylsalicylic Acid (aspirin)
- ampicillin
Interactions between your drugs
No interactions were found between Acetylsalicylic Acid and ampicillin. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Acetylsalicylic Acid
A total of 370 drugs are known to interact with Acetylsalicylic Acid.
- Acetylsalicylic acid is in the following drug classes: platelet aggregation inhibitors, salicylates.
-
Acetylsalicylic acid is used to treat the following conditions:
- Angina
- Angina Pectoris Prophylaxis
- Ankylosing Spondylitis
- Antiphospholipid Syndrome
- Aseptic Necrosis
- Back Pain
- Fever
- Heart Attack
- Ischemic Stroke
- Ischemic Stroke, Prophylaxis
- Juvenile Rheumatoid Arthritis
- Kawasaki Disease
- Myocardial Infarction, Prophylaxis
- Niacin Flush
- Osteoarthritis
- Pain
- Prevention of Thromboembolism in Atrial Fibrillation
- Prosthetic Heart Valves - Thrombosis Prophylaxis
- Prosthetic Heart Valves, Mechanical Valves - Thrombosis Prophylaxis
- Revascularization Procedures, Prophylaxis
- Rheumatic Fever
- Rheumatoid Arthritis
- Sciatica
- Spondyloarthritis
- Thromboembolic Stroke Prophylaxis
- Transient Ischemic Attack
ampicillin
A total of 70 drugs are known to interact with ampicillin.
- Ampicillin is in the drug class aminopenicillins.
-
Ampicillin is used to treat the following conditions:
- Bacteremia
- Bacterial Endocarditis Prevention
- Bacterial Infection
- Bronchitis
- Endocarditis
- Gastroenteritis
- Intraabdominal Infection
- Kidney Infections
- Leptospirosis
- Meningitis
- Middle Ear Infections
- Peritonitis
- Pharyngitis
- Pneumonia
- Prevention of Perinatal Group B Streptococcal Disease
- Septicemia
- Shigellosis
- Sinusitis
- Skin or Soft Tissue Infection
- Surgical Prophylaxis
- Typhoid Fever
- Upper Respiratory Tract Infection
- Urinary Tract Infection
Drug and food interactions
ampicillin food
Applies to: ampicillin
ADJUST DOSING INTERVAL: Certain penicillins may exhibit reduced gastrointestinal absorption in the presence of food. The therapeutic effect of the antimicrobial may be reduced.
MANAGEMENT: The interacting penicillin should be administered one hour before or two hours after meals. Penicillin V and amoxicillin are not affected by food and may be given without regard to meals.
References (6)
- Neu HC (1974) "Antimicrobial activity and human pharmacology of amoxicillin." J Infect Dis, 129, s123-31
- Welling PG, Huang H, Koch PA, Madsen PO (1977) "Bioavailability of ampicillin and amoxicillin in fasted and nonfasted subjects." J Pharm Sci, 66, p. 549-52
- McCarthy CG, Finland M (1960) "Absorption and excretion of four penicillins." N Engl J Med, 263, p. 315-26
- Cronk GA, Wheatley WB, Fellers GF, Albright H (1960) "The relationship of food intake to the absorption of potassium alpha-phenoxyethyl penicillin and potassium phenoxymethyl penicillin from the gastrointestinal tract." Am J Med Sci, 240, p. 219-25
- Klein JO, Sabath LD, Finland M (1963) "Laboratory studies on oxacillin. I: in vitro activity against staphylococci and some other bacterial pathogens. II: absorption and urinary excretion in normal young." Am J Med Sci, 245, p. 399-411
- Neuvonen PJ, Elonen E, Pentikainen PJ (1977) "Comparative effect of food on absorption of ampicillin and pivampicillin." J Int Med Res, 5, p. 71-6
aspirin food
Applies to: Acetylsalicylic Acid (aspirin)
GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.
MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.
References (1)
- (2002) "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn
aspirin food
Applies to: Acetylsalicylic Acid (aspirin)
One study has reported that coadministration of caffeine and aspirin lead to a 25% increase in the rate of appearance and 17% increase in maximum concentration of salicylate in the plasma. A significantly higher area under the plasma concentration time curve of salicylate was also reported when both drugs were administered together. The exact mechanism of this interaction has not been specified. Physicians and patients should be aware that coadministration of aspirin and caffeine may lead to higher salicylate levels faster.
References (1)
- Yoovathaworn KC, Sriwatanakul K, Thithapandha A (1986) "Influence of caffeine on aspirin pharmacokinetics." Eur J Drug Metab Pharmacokinet, 11, p. 71-6
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Report options
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.