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Acetaminophen / guaifenesin Drug Interactions

A total of 179 drugs are known to interact with acetaminophen / guaifenesin.

  • 14 major drug interactions
  • 71 moderate drug interactions
  • 94 minor drug interactions

Show all medications in the database that may interact with acetaminophen / guaifenesin.

Check for interactions with acetaminophen / guaifenesin

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Common medications checked in combination with acetaminophen / guaifenesin

  • acetaminophen / guaifenesin / phenylephrine (Mucinex Sinus-Max Severe Congestion Relief, Tylenol Sinus Severe Day, Sudafed PE Pressure+Pain+Mucus, Beechams All-in-One, Duratuss-A, LuSonex Plus, Mucinex Fast-Max Cold & Sinus, Mucinex Sinus-Max Pressure & Pain, ConRx Sinus, Histenol-Forte II, Mucinex Sinus-Max Day & Night (Day), Theraflu Warming Relief Cold and Chest Congestion, Emagrin Forte, Tylenol Cold Head Congestion Severe, Sudafed PE Triple Action, Sinus Congestion & Pain, Coldonyl, Mucinex Sinus-Max Day Time Severe Congestion Relief)
  • Advair Diskus (fluticasone / salmeterol)
  • Aralast (alpha 1-proteinase inhibitor)
  • Biaxin (clarithromycin)
  • Centrum Silver (multivitamin with minerals)
  • Coumadin (warfarin)
  • Daliresp (roflumilast)
  • Fish Oil Ultra (omega-3 polyunsaturated fatty acids)
  • Ginkgo Biloba (ginkgo)
  • guaifenesin (Mucinex, Tussin, Robafen, Robitussin Chest Congestion, Humibid, Guaifenesin LA, Guaiatussin, Guiatuss, Siltussin, Guaifenex LA, Tussin Expectorant, Fenesin, Guaifenex G, Mucus Relief, Organ-1 NR, Liquibid, Breonesin, GG 200 NR, Glytuss, Mytussin, Q-Tussin, Sorbutuss, Robitussin Mucus + Chest Congestion, Diabetic Tuss, Balminil Expectorant, Xpect, Strepsils Chesty Cough, Kenkay Chesty Cough Eexpectorant, Liquituss GG, Siltussin DAS, Organidin NR, Benadryl Chesty Forte, G Bid, Touro EX, Pneumomist, Ganidin NR, Iofen-NF, Humibid Pediatric, Iodrol NR, Mucinex Children's Chest Congestion, Guaibid-LA, Aquamist, Q-Bid LA, Amibid LA, Mucobid-LA, Fenex-LA, Muco-Fen LA, Muco-Fen 800, Scot-Tussin Expectorant, Humavent LA, Guiacough, Lotussin, Altarussin, Anti-Tuss, Diabetic Expectorant, Allfen Jr, Genatuss, Halotussin, Mastussin, Ri-Tussin, Robichem, Siltuss DAS, T-Tussin, Tusscidin, Gua-SR, Humigen LA, Sinumist, Altorant, Duratuss G, Naldecon-EX Senior, Phanasin, Iophen NR, GG-Cen, Muco-Fen 1200, Liquidbid LA, Liquidbid 1200, Benylin E, Calmylin Expectorant, Guiadrine G-1200, Siltussin DAS-NA, Iofen, Muco-Fen, Drituss G, Beechams Veno's for Kids Chesty Cough, Junior Meltus Colour and Sugar Free Expectorant, Help I Have Chest Congestion, Tixylix Chesty Cough, Bidex-400, Humibid E, Fenesin IR, Hill's Balsam Chesty Cough, Jackson's Extra Strength All Fours, Junior Meltus Chesty Coughs with Catarrh, Liqufruta Garlic Cough Medicine, Family Meltus Chesty Coughs, Jackson's The Original All Fours, Beechams Veno's Expectorant, Lemsip Cough Chesty, Respa-GF, Nirolex Chesty Cough, Dristan Chesty Cough, Nyal Chesty Cough, Pharmacist Expectorant, Dristan Chesty Cough Guaiphenesin, Mucinex for Kids, Guaifen NR, Buckley's Chest Congestion, Lloydspharmacy Expectorant Adult Cough, Lloydspharmacy Expectorant Junior Cough, TabTussin 400, Diabetic Tussin Mucus Relief, Refenesen Chest Congestion Relief, Bronchoril, Hytuss, Actifed CC Chesty Cough, Mucaplex, Tussin Mucus + Chest Congestion, Air Power, Mucinex Maximum Strength)
  • Guaifenesin AC (codeine / guaifenesin)
  • Lanoxin (digoxin)
  • Nevanac (nepafenac ophthalmic)
  • Niacin Flush Free (inositol)
  • Otrivin (xylometazoline nasal)
  • phenylephrine (Neo-Synephrine, Sudafed PE Congestion, Phenyl-T, Nasal Decongestant PE, Congest Aid II, Nasop, Vazculep, Suphedrine PE, Help I Have A Stuffy Nose, Despec-SF, Sudogest PE, Nasop12, Triaminic Thin Strips Cold with Stuffy Nose, Dimetapp Toddler's Drops Decongestant, AH-Chew D, Gilchew IR, Little Colds Decongestant, Lusonal, Contac-D, Ricobid-D, PediaCare Children's Decongestant, Sudafed PE Children's Nasal Decongestant)
  • Prilosec OTC (omeprazole)
  • Proventil HFA (albuterol)
  • Spiriva (tiotropium)
  • Vigamox (moxifloxacin ophthalmic)
  • Vitamin B12 (cyanocobalamin)

acetaminophen / guaifenesin alcohol/food Interactions

There is 1 alcohol/food interaction with acetaminophen / guaifenesin

acetaminophen / guaifenesin disease Interactions

There are 3 disease interactions with acetaminophen / guaifenesin which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.