Acetaminophen/dextromethorphan/guaifenesin Interactions
There are 489 drugs known to interact with acetaminophen/dextromethorphan/guaifenesin, along with 3 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 86 are major, 376 are moderate, and 27 are minor.
- View acetaminophen/dextromethorphan/guaifenesin alcohol/food interactions (1)
- View acetaminophen/dextromethorphan/guaifenesin disease interactions (3)
Medications known to interact with acetaminophen/dextromethorphan/guaifenesin
Note: Showing generic names only.
5
A
- abametapir topical
- abiraterone
- acetylcarbromal
- acrivastine
- adagrasib
- adalimumab
- alefacept
- alfentanil
- allopurinol
- almotriptan
- alprazolam
- amiodarone
- amisulpride
- amitriptyline
- amobarbital
- amoxapine
- amphetamine
- anagrelide
- anakinra
- anisindione
- apalutamide
- apomorphine
- apraclonidine ophthalmic
- aripiprazole
- asenapine
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- atezolizumab
- atomoxetine
- atropine
- avelumab
- azatadine
- azelastine nasal
B
- baclofen
- bedaquiline
- belladonna
- benoxinate ophthalmic
- benzocaine topical
- benzphetamine
- benztropine
- berotralstat
- bimekizumab
- biperiden
- black cohosh
- brentuximab
- brexanolone
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- brodalumab
- bromocriptine
- brompheniramine
- bupivacaine
- bupivacaine liposome
- buprenorphine
- bupropion
- buspirone
- busulfan
- butabarbital
- butalbital
- butorphanol
C
- calaspargase pegol
- canakinumab
- cannabidiol
- cannabis
- capivasertib
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- celecoxib
- cemiplimab
- cenobamate
- ceritinib
- charcoal
- chlophedianol
- chloral hydrate
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chloroprocaine
- chloroprocaine ophthalmic
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorzoxazone
- cholestyramine
- cimetidine
- cinacalcet
- citalopram
- clemastine
- clidinium
- clobazam
- clofarabine
- clomipramine
- clonazepam
- clonidine
- clorazepate
- clozapine
- cobicistat
- cocaine nasal
- cocaine topical
- codeine
- cosibelimab
- cyclizine
- cyclobenzaprine
- cyproheptadine
D
- daclizumab
- dacomitinib
- danicopan
- dantrolene
- daridorexant
- darifenacin
- deferasirox
- delavirdine
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexbrompheniramine
- dexchlorpheniramine
- dexfenfluramine
- dexmedetomidine
- dextroamphetamine
- dezocine
- diazepam
- dibucaine topical
- dicumarol
- dicyclomine
- difelikefalin
- diflunisal
- dihydroergotamine
- dimenhydrinate
- diphenhydramine
- divalproex sodium
- dolasetron
- dostarlimab
- doxepin
- doxepin topical
- doxylamine
- dronabinol
- dronedarone
- droperidol
- duloxetine
- durvalumab
E
- echinacea
- efavirenz
- elacestrant
- eletriptan
- eliglustat
- emapalumab
- encorafenib
- entacapone
- epcoritamab
- epirubicin
- ergotamine
- escitalopram
- esketamine
- eslicarbazepine
- estazolam
- eszopiclone
- ethanol
- ethchlorvynol
- ethinyl estradiol
- ethosuximide
- ethotoin
- etidocaine
- etranacogene dezaparvovec
- ezogabine
F
- fedratinib
- felbamate
- fenfluramine
- fenofibrate
- fenoldopam
- fentanyl
- fexinidazole
- fidanacogene elaparvovec
- flavoxate
- flibanserin
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- fosphenytoin
- fostamatinib
- frovatriptan
- furazolidone
G
- gabapentin
- gabapentin enacarbil
- ganaxolone
- gepirone
- givosiran
- glofitamab
- glycerol phenylbutyrate
- glycopyrrolate
- golimumab
- granisetron
- guanfacine
- guselkumab
H
- halazepam
- halofantrine
- haloperidol
- heroin
- hydrocodone
- hydromorphone
- hydroxychloroquine
- hydroxyprogesterone
- hydroxyzine
- hyoscyamine
I
- idelalisib
- iloperidone
- imatinib
- imipramine
- infliximab
- interferon beta-1a
- interferon beta-1b
- ipilimumab
- isocarboxazid
- isoniazid
K
L
- lamotrigine
- lasmiditan
- leflunomide
- lemborexant
- lenacapavir
- leniolisib
- levetiracetam
- levobupivacaine
- levodopa
- levoketoconazole
- levomethadyl acetate
- levomilnacipran
- levorphanol
- lidocaine
- lidocaine ophthalmic
- lidocaine otic
- lidocaine topical
- linezolid
- liraglutide
- lisdexamfetamine
- lithium
- lofexidine
- lomitapide
- lonapegsomatropin
- lorazepam
- lorcaserin
- lorlatinib
- loxapine
- lumateperone
- lurasidone
M
- maprotiline
- mavorixafor
- mazindol
- meclizine
- melatonin
- memantine
- mepenzolate
- meperidine
- mephenytoin
- mephobarbital
- mepivacaine
- meprobamate
- mesoridazine
- metaxalone
- methadone
- methamphetamine
- methdilazine
- methocarbamol
- methohexital
- methotrexate
- methotrimeprazine
- methscopolamine
- methsuximide
- methyldopa
- methylene blue
- metoclopramide
- metyrosine
- mibefradil
- midazolam
- milnacipran
- mipomersen
- mirabegron
- mirtazapine
- mitotane
- molindone
- morphine
- morphine liposomal
N
- nabilone
- nalbuphine
- naltrexone
- naratriptan
- nefazodone
- nemolizumab
- nicotine
- nilotinib
- niraparib
- nivolumab
- nortriptyline
O
- olanzapine
- oliceridine
- olutasidenib
- omaveloxolone
- ondansetron
- opicapone
- opium
- oritavancin
- orphenadrine
- osilodrostat
- ospemifene
- oxamniquine
- oxazepam
- oxcarbazepine
- oxybutynin
- oxycodone
- oxymorphone
- ozanimod
P
- paliperidone
- palonosetron
- panobinostat
- paraldehyde
- paramethadione
- paroxetine
- pegaspargase
- peginterferon beta-1a
- pembrolizumab
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perphenazine
- pexidartinib
- phenacemide
- phenelzine
- phenindamine
- phenobarbital
- phensuximide
- phentermine
- phenytoin
- pimozide
- pirtobrutinib
- pitolisant
- pneumococcal 13-valent vaccine
- pneumococcal 15-valent conjugate vaccine
- pneumococcal 20-valent conjugate vaccine
- pneumococcal 21-valent conjugate vaccine
- pneumococcal 7-valent vaccine
- pralsetinib
- pramipexole
- pramoxine topical
- pregabalin
- pretomanid
- primidone
- probenecid
- procaine
- procarbazine
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propafenone
- propantheline
- proparacaine ophthalmic
- propiomazine
- propoxyphene
- propranolol
- protriptyline
- pyrilamine
Q
R
- ramelteon
- ranitidine
- ranitidine bismuth citrate
- ranolazine
- rasagiline
- remdesivir
- remifentanil
- remimazolam
- retifanlimab
- rifampin
- rilonacept
- risperidone
- ritlecitinib
- ritonavir
- rizatriptan
- rolapitant
- ropeginterferon alfa-2b
- ropinirole
- ropivacaine
- rotigotine
- rucaparib
- rufinamide
S
- safinamide
- sarilumab
- satralizumab
- scopolamine
- secobarbital
- secukinumab
- selegiline
- sertraline
- sibutramine
- siltuximab
- sodium salicylate
- solifenacin
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- st. john's wort
- stiripentol
- sufentanil
- sulfinpyrazone
- sumatriptan
- suvorexant
T
- tafamidis
- tapentadol
- tarlatamab
- tasimelteon
- tebentafusp
- teclistamab
- tedizolid
- temazepam
- terbinafine
- teriflunomide
- tetrabenazine
- tetracaine
- tetracaine ophthalmic
- tetracaine topical
- thalidomide
- thiethylperazine
- thioguanine
- thiopental
- thioridazine
- thiothixene
- tiagabine
- ticlopidine
- tislelizumab
- tizanidine
- tocilizumab
- tolcapone
- tolterodine
- topiramate
- toripalimab
- trabectedin
- tramadol
- tranylcypromine
- trazodone
- tremelimumab
- triazolam
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- troglitazone
- trospium
- tryptophan
U
V
- valbenazine
- valdecoxib
- valerian
- valoctocogene roxaparvovec
- valproic acid
- varenicline
- vemurafenib
- venlafaxine
- vigabatrin
- vilazodone
- viloxazine
- vimseltinib
- vortioxetine
W
Z
Acetaminophen/dextromethorphan/guaifenesin alcohol/food interactions
There is 1 alcohol/food interaction with acetaminophen / dextromethorphan / guaifenesin.
Acetaminophen/dextromethorphan/guaifenesin disease interactions
There are 3 disease interactions with acetaminophen / dextromethorphan / guaifenesin which include:
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.