Acetaminophen / dextromethorphan / guaifenesin / oxymetazoline / phenylephrine Drug Interactions
A total of 492 drugs are known to interact with acetaminophen / dextromethorphan / guaifenesin / oxymetazoline / phenylephrine.
- 67 major drug interactions
- 409 moderate drug interactions
- 16 minor drug interactions
Check for interactions
Medications known to interact with acetaminophen / dextromethorphan / guaifenesin / oxymetazoline / phenylephrine
Note: Showing generic names only.
A
- abametapir topical
- abiraterone
- acarbose
- acebutolol
- acetohexamide
- acetylcarbromal
- albiglutide
- albuterol
- alogliptin
- alprazolam
- amiodarone
- amitriptyline
- amobarbital
- amoxapine
- amphetamine
- anagrelide
- anisindione
- apalutamide
- apomorphine
- apraclonidine ophthalmic
- arformoterol
- aripiprazole
- asenapine
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- atenolol
- atomoxetine
- atropine
- atropine ophthalmic
- azatadine
- azelastine nasal
B
- baclofen
- bedaquiline
- belladonna
- benoxinate ophthalmic
- benzocaine topical
- benzphetamine
- benztropine
- betaxolol
- betaxolol ophthalmic
- biperiden
- bisoprolol
- bitolterol
- black cohosh
- brentuximab
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- bromocriptine
- brompheniramine
- buprenorphine
- bupropion
- busulfan
- butabarbital
- butalbital
- butorphanol
C
- calaspargase pegol
- canagliflozin
- cannabidiol
- cannabis
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- carteolol
- carteolol ophthalmic
- carvedilol
- celecoxib
- cenobamate
- ceritinib
- charcoal
- chlophedianol
- chloral hydrate
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorpropamide
- chlorzoxazone
- cholestyramine
- cimetidine
- cinacalcet
- citalopram
- clemastine
- clidinium
- clobazam
- clofarabine
- clomipramine
- clonazepam
- clonidine
- clorazepate
- clozapine
- cobicistat
- cocaine nasal
- cocaine topical
- codeine
- colchicine
- cyclizine
- cyclopentolate ophthalmic
- cyproheptadine
D
- daclizumab
- dacomitinib
- dantrolene
- dapagliflozin
- dapsone
- dapsone topical
- darifenacin
- deferasirox
- delavirdine
- deserpidine
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexbrompheniramine
- dexchlorpheniramine
- dexfenfluramine
- dexmedetomidine
- dexmethylphenidate
- dextroamphetamine
- dezocine
- diazepam
- dibucaine topical
- dicumarol
- dicyclomine
- diethylpropion
- diflunisal
- digitoxin
- digoxin
- dihydroergotamine
- dimenhydrinate
- diphenhydramine
- divalproex sodium
- dolasetron
- doxapram
- doxepin
- doxylamine
- dronabinol
- dronedarone
- droperidol
- droxidopa
- dulaglutide
- duloxetine
E
- echinacea
- efavirenz
- eliglustat
- empagliflozin
- entacapone
- epirubicin
- epoprostenol
- ergonovine
- ergotamine
- ertugliflozin
- escitalopram
- esketamine
- eslicarbazepine
- esmolol
- estazolam
- eszopiclone
- ethanol
- ethchlorvynol
- ethinyl estradiol
- ethosuximide
- ethotoin
- exenatide
- ezogabine
F
- fedratinib
- felbamate
- fenfluramine
- fenofibrate
- fenoldopam
- flavoxate
- flibanserin
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- formoterol
- fosphenytoin
- fostamatinib
- furazolidone
G
- gabapentin
- gabapentin enacarbil
- givosiran
- glimepiride
- glipizide
- glyburide
- glycerol phenylbutyrate
- glycopyrrolate
- granisetron
- guanadrel
- guanethidine
H
- halazepam
- halofantrine
- haloperidol
- halothane
- heroin
- homatropine ophthalmic
- hydrocodone
- hydromorphone
- hydroxyprogesterone
- hydroxyzine
- hyoscyamine
I
- idelalisib
- iloperidone
- iloprost
- imatinib
- imipramine
- indacaterol
- insulin
- insulin aspart
- insulin aspart protamine
- insulin degludec
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin inhalation, rapid acting
- insulin isophane
- insulin lispro
- insulin lispro protamine
- insulin regular
- insulin zinc
- insulin zinc extended
- interferon beta-1a
- interferon beta-1b
- iobenguane I 123
- iobenguane I 131
- isocarboxazid
- isoetharine
- isoniazid
- isoproterenol
K
L
- labetalol
- lamotrigine
- lasmiditan
- lefamulin
- leflunomide
- lemborexant
- levalbuterol
- levetiracetam
- levobetaxolol ophthalmic
- levobunolol ophthalmic
- levodopa
- levomethadyl acetate
- levomilnacipran
- levorphanol
- levothyroxine
- lidocaine ophthalmic
- lidocaine topical
- linagliptin
- linezolid
- liothyronine
- liraglutide
- lisdexamfetamine
- lithium
- lixisenatide
- lofexidine
- lomitapide
- lorazepam
- lorcaserin
- lorlatinib
- loxapine
- lumateperone
- lurasidone
M
- ma huang
- mazindol
- mecamylamine
- meclizine
- memantine
- mepenzolate
- mephenytoin
- mephobarbital
- meprobamate
- mesoridazine
- metaproterenol
- metaxalone
- metformin
- methadone
- methamphetamine
- methdilazine
- methocarbamol
- methohexital
- methotrexate
- methotrimeprazine
- methscopolamine
- methsuximide
- methyldopa
- methylene blue
- methylergonovine
- methylphenidate
- methysergide maleate
- metipranolol ophthalmic
- metoclopramide
- metoprolol
- metyrosine
- mibefradil
- midazolam
- midodrine
- miglitol
- milnacipran
- mipomersen
- mirabegron
- mirtazapine
- molindone
- morphine
- morphine liposomal
N
O
- olanzapine
- oliceridine
- olodaterol
- ondansetron
- opicapone
- opium
- orphenadrine
- ospemifene
- oxamniquine
- oxazepam
- oxcarbazepine
- oxybutynin
- oxycodone
- oxymorphone
- oxytocin
- ozanimod
P
- paliperidone
- palonosetron
- panobinostat
- paraldehyde
- paramethadione
- paroxetine
- pegaspargase
- peginterferon beta-1a
- penbutolol
- pentobarbital
- perampanel
- pergolide
- perphenazine
- pexidartinib
- phenacemide
- phendimetrazine
- phenelzine
- phenindamine
- phenobarbital
- phensuximide
- phentermine
- phenylpropanolamine
- phenytoin
- pimozide
- pindolol
- pioglitazone
- pirbuterol
- pitolisant
- pneumococcal 13-valent vaccine
- pneumococcal 7-valent vaccine
- pramipexole
- pramlintide
- pregabalin
- prilocaine
- primidone
- probenecid
- procarbazine
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propafenone
- propantheline
- proparacaine ophthalmic
- propiomazine
- propoxyphene
- propranolol
- protriptyline
- pyrilamine
Q
R
- racepinephrine
- ramelteon
- ranitidine
- ranitidine bismuth citrate
- ranolazine
- rasagiline
- rauwolfia serpentina
- remdesivir
- remimazolam
- repaglinide
- reserpine
- rifampin
- risperidone
- ritodrine
- ritonavir
- rolapitant
- ropinirole
- rosiglitazone
- rotigotine
- rucaparib
- rufinamide
S
- safinamide
- salmeterol
- saxagliptin
- scopolamine
- scopolamine ophthalmic
- secobarbital
- selegiline
- selexipag
- semaglutide
- sertraline
- sibutramine
- sitagliptin
- sodium nitrite
- sodium salicylate
- solifenacin
- solriamfetol
- somapacitan-beco
- somatrem
- somatropin
- sotalol
- stiripentol
- sulfinpyrazone
- suvorexant
T
- tafamidis
- tapentadol
- tasimelteon
- temazepam
- terbinafine
- terbutaline
- teriflunomide
- tetrabenazine
- tetracaine ophthalmic
- tetracaine topical
- thalidomide
- thiethylperazine
- thioguanine
- thiopental
- thioridazine
- thiothixene
- thyroid desiccated
- tiagabine
- ticlopidine
- timolol
- timolol ophthalmic
- tizanidine
- tolazamide
- tolbutamide
- tolcapone
- tolterodine
- topiramate
- trabectedin
- tranylcypromine
- trazodone
- treprostinil
- triazolam
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- troglitazone
- tropicamide ophthalmic
- trospium
V
- valbenazine
- valdecoxib
- valerian
- valproic acid
- vemurafenib
- venlafaxine
- vigabatrin
- vilazodone
- vortioxetine
W
Z
Acetaminophen / dextromethorphan / guaifenesin / oxymetazoline / phenylephrine alcohol/food interactions
There is 1 alcohol/food interaction with acetaminophen / dextromethorphan / guaifenesin / oxymetazoline / phenylephrine
Acetaminophen / dextromethorphan / guaifenesin / oxymetazoline / phenylephrine disease interactions
There are 11 disease interactions with acetaminophen / dextromethorphan / guaifenesin / oxymetazoline / phenylephrine which include:
- alcoholism
- liver disease
- cardiovascular disease
- PKU
- psychiatric conditions
- BPH
- diabetes
- glaucoma
- BPH
- cardiovascular
- diabetes
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
