Acetaminophen/aspirin/diphenhydramine Drug Interactions
Currently displaying a list of 810 drugs known to interact with acetaminophen / aspirin / diphenhydramine.
- 82 major drug interactions
- 700 moderate drug interactions
- 28 minor drug interactions
Medications known to interact with acetaminophen/aspirin/diphenhydramine
Note: Showing generic names only.
A
- abciximab
- abiraterone
- abobotulinumtoxinA
- abrocitinib
- acalabrutinib
- acebutolol
- acetazolamide
- acetohexamide
- acetylcarbromal
- acetylcholine ophthalmic
- aclidinium
- acrivastine
- adagrasib
- ado-trastuzumab emtansine
- aducanumab
- aldesleukin
- alemtuzumab
- alendronate
- alfentanil
- alfuzosin
- aliskiren
- allopurinol
- alprazolam
- alteplase
- aluminum carbonate
- aluminum hydroxide
- amantadine
- ambenonium
- amikacin
- amikacin liposome
- amiloride
- amiodarone
- amitriptyline
- amlodipine
- amobarbital
- amoxapine
- amyl nitrite
- anacaulase topical
- anagrelide
- anisindione
- anistreplase
- apalutamide
- apixaban
- apomorphine
- apraclonidine ophthalmic
- aprocitentan
- ardeparin
- argatroban
- aripiprazole
- asenapine
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- atenolol
- atezolizumab
- atomoxetine
- atropine
- avapritinib
- avelumab
- azatadine
- azelastine nasal
- azilsartan medoxomil
B
- baclofen
- baricitinib
- bedaquiline
- belladonna
- benazepril
- bendroflumethiazide
- benoxinate ophthalmic
- benzgalantamine
- benzocaine topical
- benzthiazide
- benztropine
- bepridil
- berotralstat
- betamethasone
- betaxolol
- betiatide
- betrixaban
- biperiden
- bismuth subsalicylate
- bisoprolol
- black cohosh
- brentuximab
- bretylium
- brexanolone
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- brinzolamide ophthalmic
- brivaracetam
- bromfenac
- bromfenac ophthalmic
- bromocriptine
- brompheniramine
- budesonide
- bumetanide
- bupivacaine
- bupivacaine liposome
- buprenorphine
- bupropion
- buspirone
- busulfan
- butabarbital
- butalbital
- butorphanol
C
- cabozantinib
- caffeine
- calaspargase pegol
- calcium carbonate
- candesartan
- cannabidiol
- cannabis
- capivasertib
- caplacizumab
- capsicum
- captopril
- carbachol ophthalmic
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- carteolol
- carvedilol
- celecoxib
- cemiplimab
- cenobamate
- ceritinib
- cetirizine
- cevimeline
- chamomile
- charcoal
- chlophedianol
- chloral hydrate
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chloroprocaine
- chloroprocaine ophthalmic
- chlorothiazide
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorpropamide
- chlorthalidone
- chlorzoxazone
- cholestyramine
- choline salicylate
- cilostazol
- cimetidine
- cinoxacin
- ciprofloxacin
- citalopram
- clemastine
- clevidipine
- clidinium
- clobazam
- clofarabine
- clomipramine
- clonazepam
- clonidine
- clopidogrel
- clorazepate
- clove
- clozapine
- cobicistat
- cocaine nasal
- cocaine topical
- codeine
- collagenase clostridium histolyticum
- cortisone
- cosibelimab
- cyclizine
- cyclobenzaprine
- cyclosporine
- cyproheptadine
D
- dabigatran
- daclizumab
- dacomitinib
- dalteparin
- danaparoid
- dantrolene
- daprodustat
- daridorexant
- darifenacin
- dasatinib
- daxibotulinumtoxinA
- deferasirox
- defibrotide
- deflazacort
- delafloxacin
- demecarium bromide ophthalmic
- deoxycholic acid
- deserpidine
- desipramine
- desirudin
- desmopressin
- desvenlafaxine
- deutetrabenazine
- dexamethasone
- dexbrompheniramine
- dexchlorpheniramine
- dexfenfluramine
- dexlansoprazole
- dexmedetomidine
- dextromethorphan
- dezocine
- diazepam
- diazoxide
- dibucaine topical
- dichlorphenamide
- diclofenac
- diclofenac ophthalmic
- diclofenac topical
- dicumarol
- dicyclomine
- didanosine
- difelikefalin
- diflunisal
- digoxin
- dihydroxyaluminum sodium carbonate
- diltiazem
- dimenhydrinate
- dimethyl fumarate
- diroximel fumarate
- disopyramide
- divalproex sodium
- dofetilide
- donanemab
- donepezil
- dong quai
- dorzolamide ophthalmic
- dostarlimab
- doxazosin
- doxepin
- doxepin topical
- doxylamine
- dronabinol
- dronedarone
- droperidol
- drospirenone
- drotrecogin alfa
- duloxetine
- durvalumab
E
- echinacea
- echothiophate iodide ophthalmic
- edoxaban
- edrophonium
- efavirenz
- eliglustat
- eluxadoline
- enalapril
- enalaprilat
- encorafenib
- enoxacin
- enoxaparin
- entacapone
- epirubicin
- eplerenone
- epoprostenol
- eprosartan
- eptifibatide
- erlotinib
- escitalopram
- esketamine
- eslicarbazepine
- esmolol
- esomeprazole
- estazolam
- eszopiclone
- ethacrynic acid
- ethanol
- ethchlorvynol
- ethinyl estradiol
- ethosuximide
- ethotoin
- etidocaine
- etidronate
- etodolac
- etranacogene dezaparvovec
- evening primrose
- ezogabine
F
- fedratinib
- felbamate
- felodipine
- fenfluramine
- fenofibrate
- fenoldopam
- fenoprofen
- fentanyl
- fenugreek
- fesoterodine
- feverfew
- fexinidazole
- fidanacogene elaparvovec
- flavoxate
- flibanserin
- fludrocortisone
- fluoxetine
- fluphenazine
- flurazepam
- flurbiprofen
- flurbiprofen ophthalmic
- fluvoxamine
- fondaparinux
- fosinopril
- fosphenytoin
- fospropofol
- furazolidone
- furosemide
G
- gabapentin
- gabapentin enacarbil
- galantamine
- ganaxolone
- garlic
- gatifloxacin
- gemifloxacin
- gentamicin
- ginger
- ginkgo
- ginseng
- givosiran
- glimepiride
- glipizide
- glyburide
- glycerol phenylbutyrate
- glycopyrrolate
- glycopyrronium topical
- grepafloxacin
- griseofulvin
- guanabenz
- guanadrel
- guanethidine
- guanfacine
H
- halazepam
- haloperidol
- hemin
- heparin
- heparin flush
- heroin
- histamine phosphate
- horse chestnut
- house dust mite allergen extract
- hyaluronidase
- hydralazine
- hydrochlorothiazide
- hydrocodone
- hydrocortisone
- hydroflumethiazide
- hydromorphone
- hydroxyprogesterone
- hydroxyzine
- hyoscyamine
I
- ibandronate
- ibritumomab
- ibrutinib
- ibuprofen
- ibutilide
- icosapent
- idelalisib
- ifosfamide
- iloperidone
- iloprost
- imatinib
- imipramine
- incobotulinumtoxinA
- indapamide
- indomethacin
- influenza virus vaccine, h1n1, live
- influenza virus vaccine, live
- inotersen
- insulin
- insulin aspart
- insulin aspart protamine
- insulin degludec
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin inhalation, rapid acting
- insulin isophane
- insulin lispro
- insulin lispro protamine
- insulin regular
- insulin zinc
- insulin zinc extended
- interferon beta-1a
- interferon beta-1b
- iodine i 131 tositumomab
- ipilimumab
- ipratropium
- ipratropium nasal
- irbesartan
- isocarboxazid
- isoflurophate ophthalmic
- isoniazid
- isosorbide dinitrate
- isosorbide mononitrate
- isradipine
K
L
- labetalol
- lamotrigine
- landiolol
- lansoprazole
- lasmiditan
- lecanemab
- leflunomide
- lemborexant
- leniolisib
- lepirudin
- lesinurad
- letibotulinumtoxinA
- levamlodipine
- levetiracetam
- levobupivacaine
- levocetirizine
- levodopa
- levofloxacin
- levoketoconazole
- levomethadyl acetate
- levomilnacipran
- levorphanol
- lidocaine
- lidocaine ophthalmic
- lidocaine otic
- lidocaine topical
- linezolid
- liraglutide
- lisinopril
- lithium
- lofexidine
- lomefloxacin
- lomitapide
- loperamide
- lorazepam
- lorcaserin
- lorlatinib
- losartan
- loxapine
- lumateperone
- lurasidone
M
- macimorelin
- magaldrate
- magnesium carbonate
- magnesium hydroxide
- magnesium oxide
- magnesium salicylate
- maprotiline
- mavorixafor
- meclizine
- meclofenamate
- mefenamic acid
- melatonin
- meloxicam
- mepenzolate
- meperidine
- mephenytoin
- mephobarbital
- mepivacaine
- meprobamate
- mesoridazine
- metaxalone
- methadone
- methazolamide
- methdilazine
- methocarbamol
- methohexital
- methotrexate
- methotrimeprazine
- methscopolamine
- methsuximide
- methyclothiazide
- methyldopa
- methylprednisolone
- metoclopramide
- metolazone
- metoprolol
- metyrosine
- mibefradil
- midazolam
- mifepristone
- milnacipran
- minoxidil
- mipomersen
- mirabegron
- mirtazapine
- mitotane
- mixed grass pollens allergen extract
- moexipril
- molindone
- monomethyl fumarate
- morphine
- morphine liposomal
- moxifloxacin
N
- nabilone
- nabumetone
- nadolol
- nalbuphine
- nalidixic acid
- naltrexone
- naproxen
- nateglinide
- nebivolol
- nefazodone
- nepafenac ophthalmic
- netilmicin
- niacin
- nicardipine
- nicotinamide
- nicotine
- nifedipine
- nilotinib
- nimodipine
- nintedanib
- niraparib
- nisoldipine
- nitroglycerin
- nitroprusside
- nivolumab
- norfloxacin
- nortriptyline
O
- ofloxacin
- olanzapine
- oliceridine
- olmesartan
- olopatadine nasal
- olutasidenib
- omacetaxine
- omaveloxolone
- omega-3 polyunsaturated fatty acids
- omeprazole
- onabotulinumtoxinA
- opicapone
- opium
- oritavancin
- orphenadrine
- ospemifene
- oxaprozin
- oxazepam
- oxcarbazepine
- oxybutynin
- oxycodone
- oxymorphone
P
- paliperidone
- pamidronate
- panobinostat
- pantoprazole
- papaverine
- paraldehyde
- paramethadione
- paroxetine
- peanut allergen powder
- pegaspargase
- peginterferon beta-1a
- pembrolizumab
- pemetrexed
- penbutolol
- pentazocine
- pentobarbital
- pentosan polysulfate sodium
- pentoxifylline
- perampanel
- pergolide
- perindopril
- perphenazine
- pexidartinib
- phenacemide
- phenelzine
- phenindamine
- phenobarbital
- phenoxybenzamine
- phensuximide
- phentolamine
- phenylbutazone
- phenytoin
- physostigmine
- physostigmine ophthalmic
- pilocarpine ophthalmic
- pimozide
- pindolol
- piroxicam
- pirtobrutinib
- pitolisant
- plasminogen, human
- plazomicin
- pneumococcal 13-valent vaccine
- pneumococcal 15-valent conjugate vaccine
- pneumococcal 20-valent conjugate vaccine
- pneumococcal 21-valent conjugate vaccine
- pneumococcal 7-valent vaccine
- polyethylene glycol 3350 with electrolytes
- polythiazide
- ponatinib
- porfimer
- potassium chloride
- potassium citrate
- prabotulinumtoxinA
- pralatrexate
- pralsetinib
- pramipexole
- pramoxine topical
- prasugrel
- prazosin
- prednisolone
- prednisone
- pregabalin
- primidone
- probenecid
- procainamide
- procaine
- procarbazine
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propantheline
- proparacaine ophthalmic
- propiomazine
- propofol
- propoxyphene
- propranolol
- protriptyline
- prucalopride
- pyridostigmine
- pyrilamine
Q
R
- rabeprazole
- ragweed pollen allergen extract
- ramelteon
- ramipril
- ramucirumab
- ranitidine
- ranitidine bismuth citrate
- ranolazine
- rasagiline
- rauwolfia serpentina
- regorafenib
- remdesivir
- remifentanil
- remimazolam
- repaglinide
- reserpine
- reteplase
- retifanlimab
- revefenacin
- rifampin
- rimabotulinumtoxinB
- riociguat
- risedronate
- risperidone
- ritlecitinib
- rivaroxaban
- rivastigmine
- rizatriptan
- rofecoxib
- rolapitant
- ropeginterferon alfa-2b
- ropinirole
- ropivacaine
- rotigotine
- rucaparib
- rufinamide
S
- safinamide
- salsalate
- scopolamine
- secobarbital
- selegiline
- selumetinib
- sertraline
- sibutramine
- silodosin
- sodium acetate
- sodium bicarbonate
- sodium citrate
- sodium iodide i-123
- sodium iodide-i-131
- sodium lactate
- sodium oxybate
- sodium salicylate
- sodium thiosalicylate
- solifenacin
- sotalol
- sparfloxacin
- sparsentan
- spironolactone
- st. john's wort
- stiripentol
- streptokinase
- streptomycin
- sufentanil
- sulfinpyrazone
- sulindac
- suprofen ophthalmic
- suvorexant
T
- tacrine
- tafamidis
- tafasitamab
- tamoxifen
- tamsulosin
- tapentadol
- tasimelteon
- telmisartan
- temazepam
- tenecteplase
- terazosin
- teriflunomide
- tetrabenazine
- tetracaine
- tetracaine ophthalmic
- tetracaine topical
- thalidomide
- thiethylperazine
- thioguanine
- thiopental
- thioridazine
- thiothixene
- tiagabine
- ticagrelor
- ticlopidine
- tiludronate
- timolol
- timolol ophthalmic
- timothy grass pollen allergen extract
- tinzaparin
- tiotropium
- tipranavir
- tirofiban
- tirzepatide
- tislelizumab
- tizanidine
- tobramycin
- tofacitinib
- tolazamide
- tolbutamide
- tolcapone
- tolmetin
- tolterodine
- topiramate
- toripalimab
- torsemide
- tositumomab
- tovorafenib
- trabectedin
- tramadol
- trandolapril
- tranylcypromine
- trazodone
- tremelimumab
- treprostinil
- triamcinolone
- triamcinolone ophthalmic
- triamterene
- triazolam
- trichlormethiazide
- trichophyton skin test
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethaphan camsylate
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- tromethamine
- trospium
- trovafloxacin
- turmeric
U
V
- vadadustat
- valbenazine
- valdecoxib
- valerian
- valoctocogene roxaparvovec
- valproic acid
- valsartan
- vamorolone
- varenicline
- varicella virus vaccine
- vemurafenib
- venlafaxine
- verapamil
- verteporfin
- vigabatrin
- vilazodone
- vitamin e
- voclosporin
- vortioxetine
W
Z
- zafirlukast
- zaleplon
- zanubrutinib
- ziconotide
- zidovudine
- ziprasidone
- zoledronic acid
- zolpidem
- zonisamide
- zuranolone
Acetaminophen/aspirin/diphenhydramine alcohol/food interactions
There are 3 alcohol/food interactions with acetaminophen / aspirin / diphenhydramine.
Acetaminophen/aspirin/diphenhydramine disease interactions
There are 20 disease interactions with acetaminophen / aspirin / diphenhydramine which include:
- alcoholism
- liver disease
- depression
- coagulation
- asthma
- GI toxicity
- renal dysfunction
- Reye's syndrome
- PKU
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
- anemia
- dialysis
- G-6-PD deficiency
- hepatotoxicity
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
