Zavegepant Dosage

Medically reviewed by Drugs.com. Last updated on Aug 16, 2023.

Usual Adult Dose for Migraine

For acute treatment of migraine: Nasal spray: 10 mg given as a single spray in one nostril, as needed
Maximum dose: 10 mg (one spray) in a 24-hour period

Comments:

• The safety of treating more than 8 migraines in a 30-day period is unknown.

Use: For the acute treatment of migraine with or without aura in adults.

Renal Dose Adjustments

CrCl greater than 30 mL/min: No adjustment recommended
CrCl less than 30 mL/min: Avoid use

Liver Dose Adjustments

• Mild to Moderate Liver Dysfunction (Child-Pugh Class A and B): No adjustment recommended
• Severe Liver Dysfunction (Child-Pugh Class C): Avoid use

Precautions

US FDA requires a medication guide to assure safe use. For additional information: www.fda.gov/drugs/drug-safety-and-availability/medication-guides

CONTRAINDICATIONS: Hypersensitivity to active substance or any product excipients

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• Nasal spray: Use one 10 mg spray in one nostril as needed
• Do not test spray, prime, or press the plunger before use.
• The manufacturer product information and instructions for use should be consulted prior to product administration.
• Do not administer this drug with intranasal decongestants; if use cannot be avoided, use decongestant at least 1 hour after using this drug.

Storage requirements:

• Store at 20C to 25C (68F to 77F); excursions from 15C to 30C (59F to 86F) are permitted.
• Do not freeze.

General:

• Supplied as single-use unit-dosed nasal spray devices each containing 10 mg of drug

Patient advice:

• Consult the Patient Information and Instructions for Use prior to utilization of this medication.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer