Vismodegib Dosage
Medically reviewed by Drugs.com. Last updated on Apr 10, 2019.
Applies to the following strengths: 150 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Basal Cell Carcinoma
Usual adult dose: 150 mg orally once a day
Duration of therapy: Until disease progression or until unacceptable toxicity.
Use: Treatment of adults with metastatic basal cell carcinoma, or with locally advanced basal cell carcinoma that has recurred following surgery or who are not candidates for surgery, and who are not candidates for radiation.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Dose Adjustments
No dosage adjustment is recommended based on gender, weight, or age.
Precautions
US BOXED WARNING:
-Vismodegib can result in embryo-fetal death or severe birth defects.
-Vismodegib is embryotoxic and teratogenic in animals. Teratogenic effects included severe midline defects, missing digits, and other irreversible malformations.
-Verify pregnancy status prior to the initiation of vismodegib. Advise male and female patients of these risks. Advise female patients of the need for contraception and advise male patients of the potential risk of vismodegib exposure through semen.
Safety and efficacy have not been established in patients younger than 18 years.
Dialysis
Data not available
Other Comments
Administration advice:
-May be taken with or without food.
-Swallow capsules whole; do not open or crush capsules.
-If a dose of is missed, do not make up that dose; resume dosing with the next scheduled dose.
Monitoring:
-Pregnancy
Patient advice:
-Advise patients that exposure during pregnancy can cause embryo-fetal death or severe birth defects.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about vismodegib
Consumer resources
Other brands: Erivedge
