Medically reviewed on March 19, 2018.
Applies to the following strengths: 50 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Amyotrophic Lateral Sclerosis
50 mg orally twice a day
Renal Dose Adjustments
Use with caution
Liver Dose Adjustments
Not recommended in patients with baseline elevations of serum aminotransferases greater than 5 times the upper limit of normal or evidence of liver dysfunction (e.g. elevated bilirubin)
Discontinue therapy if hepatic transaminases increase to greater than 5 x ULN
Discontinue therapy if there is evidence of liver dysfunction (e.g. elevated bilirubin)
-Hypersensitivity to active substance or any product components; anaphylaxis has been reported
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Data not available.
-Take orally at least 1 hour before or 2 hours after a meal
-Clinical studies have shown the time to tracheostomy or death was longer for patients receiving this drug compared with placebo.
-Measures of muscle strength and neurological function did not show benefit with this drug.
-Obtain baseline serum aminotransferases levels and repeat as clinically indicated
-Monitor for signs and symptoms of hepatic toxicity monthly for first 3 months, then periodically thereafter
-Monitor for signs and symptoms of neutropenia, especially in first 3 months.
-Patients should be instructed to contact their healthcare provider if they experience yellowing of the whites of the eyes, fever, or respiratory symptoms such as dry cough and difficult or labored breathing.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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