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Riluzole Dosage

Medically reviewed on March 19, 2018.

Applies to the following strengths: 50 mg

Usual Adult Dose for Amyotrophic Lateral Sclerosis

50 mg orally twice a day

Renal Dose Adjustments

Use with caution

Liver Dose Adjustments

Not recommended in patients with baseline elevations of serum aminotransferases greater than 5 times the upper limit of normal or evidence of liver dysfunction (e.g. elevated bilirubin)

Discontinue therapy if hepatic transaminases increase to greater than 5 x ULN
Discontinue therapy if there is evidence of liver dysfunction (e.g. elevated bilirubin)

Precautions

CONTRAINDICATIONS:
-Hypersensitivity to active substance or any product components; anaphylaxis has been reported

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available.

Other Comments

Administration advice:
-Take orally at least 1 hour before or 2 hours after a meal

General:
-Clinical studies have shown the time to tracheostomy or death was longer for patients receiving this drug compared with placebo.
-Measures of muscle strength and neurological function did not show benefit with this drug.

Monitoring:
-Obtain baseline serum aminotransferases levels and repeat as clinically indicated
-Monitor for signs and symptoms of hepatic toxicity monthly for first 3 months, then periodically thereafter
-Monitor for signs and symptoms of neutropenia, especially in first 3 months.

Patient advice:
-Patients should be instructed to contact their healthcare provider if they experience yellowing of the whites of the eyes, fever, or respiratory symptoms such as dry cough and difficult or labored breathing.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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