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Generic name: sodium phenylbutyrate and taurursodiol
Dosage form: powder for oral suspension
Drug class: Miscellaneous central nervous system agents

Medically reviewed by Judith Stewart, BPharm. Last updated on Oct 11, 2022.

What is Relyvrio?

Relyvrio is a prescription medicine used to treat adults with amyotrophic lateral sclerosis (ALS), commonly referred to as Lou Gehrig’s disease.

ALS is a neurodegenerative disease caused by motor neuron death in the brain and spinal cord.

The two ingredients contained in Relyvrio work together to reduce motor neuron cell death and inflammation, and slow down disease progression.

What is Relyvrio used to treat?

Relyvrio is used to treat adults with amyotrophic lateral sclerosis (ALS).

Motor neuron loss in ALS leads to deteriorating muscle function, the inability to move and speak, respiratory paralysis, and eventually death.

It is not known if this medicine is safe and effective in children.

Before taking Relyvrio

Before you start treatment, tell your healthcare provider about all of your medical conditions, including if you:

What other drugs will affect Relyvrio?

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, and any taurursodiol products, such as tauroursodeoxycholic acid (TUDCA).

Relyvrio may affect the way other medicines work, and other medicines may affect how Relyvrio works.

Especially tell your doctor if you take:

There are many other drugs that may interact with Relyvrio. Check with your healthcare provider before you start treatment.

How should I take Relyvrio?

Dosing information

Usual Adult Dose for Amyotrophic Lateral Sclerosis

- The recommended dosage is 1 packet (3 g sodium phenylbutyrate and 1 g taurursodiol) daily for the first 3 weeks, and then 1 packet twice daily thereafter.

- Comment: can be administered orally or via feeding tube.

- Use: treatment of amyotrophic lateral sclerosis (ALS) in adults.

Relyvrio side effects

Relyvrio may cause serious side effects, including:

Talk to your healthcare provider about the total amount of daily salt that is right for you. Your healthcare provider will monitor you for signs and symptoms of salt retention during your treatment.

The most common side effects include:

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store Relyvrio?

Keep all medicines out of the reach of children and pets.

General information about the safe and effective use of Relyvrio.

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use this medicine for a condition for which it was not prescribed. Do not give it to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information that is written for health professionals.

What are the ingredients in Relyvrio?

Active ingredients: sodium phenylbutyrate, taurursodiol
Inactive ingredients: acacia, dibasic sodium phosphate maltodextrin, medium-chain triglycerides, mixed berry flavoring, other flavoring ingredients, silicon dioxide, sodium stearyl fumarate, sorbitol, and sucralose.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.