Generic Name: edaravone (e DAR a vone)
Brand Names: Radicava
Medically reviewed on August 13, 2017.
What is Radicava?
Radicava (edaravone) works by relieving the effects of oxidative stress, which may be related to the death of motor neurons (nerve cells) in people with Amyotrophic Lateral Sclerosis (ALS). Keeping motor neurons healthy may help to preserve muscle function.
Radicava is used to treat amyotrophic lateral sclerosis.
Radicava can cause serious allergic reactions. Get emergency medical help if you have hives, itching, trouble breathing, swelling in your face or throat, or if you feel light-headed.
Before taking this medicine
You should not be treated with Radicava if you are allergic to edaravone.
To make sure Radicava is safe for you, tell your doctor if you have ever had:
asthma or a sulfite allergy.
It is not known whether Radicava will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether edaravone passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.
How is Radicava given?
Radicava is injected into a vein through an IV. A healthcare provider will give you this injection.
Radicava is usually given in a 28-day treatment cycle. You may need to use the medicine only during the first 2 weeks of each cycle. Your doctor will determine how long to treat you with this medicine.
This medicine must be given slowly and the IV infusion can take at least 60 minutes to complete.
Radicava dosing information
Usual Adult Dose for Amyotrophic Lateral Sclerosis:
-Initial Treatment Cycle: 60 mg once a day as IV infusion for 14 days followed by a 14-day drug-free period.
-Subsequent Treatment Cycles: 60 mg once a day as IV infusion for 10 days out of 14-day periods, followed by 14-day drug-free periods.
-Administer each 60 mg dose as 2 consecutive 30 mg IV infusion bags over a total of 60 minutes (infusion rate approximately 1 mg per minute [3.33 mL per minute]).
-Upon the first observation of any signs or symptoms of a hypersensitivity reaction, promptly discontinue the infusion.
Use: Treatment of amyotrophic lateral sclerosis (ALS)
See also: Dosage Information (in more detail)
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your Radicava injection.
What happens if I overdose?
Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What should I avoid while receiving Radicava?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Radicava side effects
Radicava can cause serious allergic reactions. The symptoms may not appear until after your IV infusion is finished.
Get emergency medical help if you have signs of an allergic reaction to Radicava: hives, itching; wheezing, difficult breathing; feeling light-headed; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
bronchospasm (wheezing, chest tightness, trouble breathing); or
a light-headed feeling, like you might pass out.
Common Radicava side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Radicava?
Other drugs may interact with edaravone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Radicava only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 1.01.
More about Radicava (edaravone)
- Side Effects
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- Dosage Information
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- Drug class: miscellaneous central nervous system agents