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Propafenone Dosage

Medically reviewed by Drugs.com. Last updated on Aug 10, 2023.

Applies to the following strengths: 150 mg; 300 mg; 225 mg; 325 mg; 425 mg

Usual Adult Dose for Atrial Fibrillation

Immediate-release Tablets:
Initial dose: 150 mg orally every 8 hours; may increase dose after at least 3 to 4 days to 225 mg orally every 8 hours; if additional therapeutic effect is needed, may increase dose to 300 mg orally every 8 hours.
Maximum dose: 900 mg/day

Uses:


Extended-release Capsules:
Initial dose: 225 mg orally every 12 hours; may increase dose after at least 5 days to 325 mg orally every 12 hours; if additional therapeutic effect is needed, may increase dose to 425 mg orally every 12 hours.

Use: To prolong time to recurrence of symptomatic atrial fibrillation (AF) in patients with episodic (most likely paroxysmal or persistent) AF who do not have structural heart disease.

Usual Adult Dose for Atrial Flutter

Immediate-release Tablets:
Initial dose: 150 mg orally every 8 hours; may increase dose after at least 3 to 4 days to 225 mg orally every 8 hours; if additional therapeutic effect is needed, may increase dose to 300 mg orally every 8 hours.
Maximum dose: 900 mg/day

Uses:


Extended-release Capsules:
Initial dose: 225 mg orally every 12 hours; may increase dose after at least 5 days to 325 mg orally every 12 hours; if additional therapeutic effect is needed, may increase dose to 425 mg orally every 12 hours.

Use: To prolong time to recurrence of symptomatic atrial fibrillation (AF) in patients with episodic (most likely paroxysmal or persistent) AF who do not have structural heart disease.

Usual Adult Dose for Ventricular Tachycardia

Immediate-release Tablets:
Initial dose: 150 mg orally every 8 hours; may increase dose after at least 3 to 4 days to 225 mg orally every 8 hours; if additional therapeutic effect is needed, may increase dose to 300 mg orally every 8 hours.
Maximum dose: 900 mg/day

Uses:


Extended-release Capsules:
Initial dose: 225 mg orally every 12 hours; may increase dose after at least 5 days to 325 mg orally every 12 hours; if additional therapeutic effect is needed, may increase dose to 425 mg orally every 12 hours.

Use: To prolong time to recurrence of symptomatic atrial fibrillation (AF) in patients with episodic (most likely paroxysmal or persistent) AF who do not have structural heart disease.

Usual Adult Dose for Paroxysmal Supraventricular Tachycardia

Immediate-release Tablets:
Initial dose: 150 mg orally every 8 hours; may increase dose after at least 3 to 4 days to 225 mg orally every 8 hours; if additional therapeutic effect is needed, may increase dose to 300 mg orally every 8 hours.
Maximum dose: 900 mg/day

Uses:


Extended-release Capsules:
Initial dose: 225 mg orally every 12 hours; may increase dose after at least 5 days to 325 mg orally every 12 hours; if additional therapeutic effect is needed, may increase dose to 425 mg orally every 12 hours.

Use: To prolong time to recurrence of symptomatic atrial fibrillation (AF) in patients with episodic (most likely paroxysmal or persistent) AF who do not have structural heart disease.

Renal Dose Adjustments

Use with caution

Liver Dose Adjustments

Dose reduction may be required; however, no specific guidelines have been suggested. Caution recommended.

Dose Adjustments

Patients with significant widening of the QRS complex or second- or third-degree atrioventricular (AV) block: Dose reduction may be required; however, no specific guidelines have been suggested. Caution recommended.

Precautions

CONTRAINDICATIONS:


US BOXED WARNING:

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


General:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.