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Polymyxin B Dosage

Applies to the following strengths: 500000 units

Usual Adult Dose for Bacteremia

IM: 25,000 to 30,000 units/kg/day IM divided every 4 or 6 hours
IV: 15,000 to 25,000 units/kg/day IV divided every 12 hours

Comments:


Uses:

Usual Adult Dose for Urinary Tract Infection

IM: 25,000 to 30,000 units/kg/day IM divided every 4 or 6 hours
IV: 15,000 to 25,000 units/kg/day IV divided every 12 hours

Comments:


Uses:

Usual Adult Dose for Meningitis

Initial dose: 50,000 units intrathecally once a day for 3 to 4 days
Maintenance dose: 50,000 units intrathecally every other day
Duration of therapy: At least 2 weeks after CSF cultures are negative and sugar content normalizes

Comments:


Uses:

Usual Adult Dose for Ocular Infection

Ophthalmic:


Comments:

Uses:

Usual Pediatric Dose for Bacteremia

Infants:


Children:

Comments:

Uses:

Usual Pediatric Dose for Urinary Tract Infection

Infants:


Children:

Comments:

Uses:

Usual Pediatric Dose for Sepsis

Infants:


Children:

Comments:

Uses:

Usual Pediatric Dose for Meningitis

Children under 2 years:


Children over 2 years:

Duration of therapy: At least 2 weeks after CSF cultures are negative and sugar content normalizes

Comments:

Uses:

Renal Dose Adjustments

Renal Dysfunction:

Liver Dose Adjustments

Data not available

Precautions

US BOXED WARNINGS:


CONTRAINDICATIONS:
Prior history of hypersensitivity reactions to polymyxins

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


Storage requirements:

Reconstitution/preparation techniques:

IV compatibility:

Monitoring:

Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.