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Coly Mycin M

Generic name: colistimethatekoe-LIS-ti-METH-ate ]
Drug classes: Inhaled anti-infectives, Miscellaneous antibiotics

Medically reviewed by on Apr 9, 2024. Written by Cerner Multum.

What is Coly Mycin M?

Coly Mycin M is an antibiotic that fights bacteria.

Coly Mycin M is used to treat infections caused by bacteria.

Coly Mycin M may also be used for purposes not listed in this medication guide.

Coly Mycin M side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Coly Mycin M may cause serious side effects. Call your doctor at once if you have:

Common side effects of Coly Mycin M may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use Coly Mycin M if you are allergic to it.

To make sure Coly Mycin M is safe for you, tell your doctor if you have:

It is not known whether Coly Mycin M will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether colistimethate passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.

How is Coly Mycin M given?

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Coly Mycin M is injected into a muscle, or into a vein through an IV. You may be shown how to use injections at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.

Coly Mycin M is a powder medicine that must be mixed with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.

After mixing Coly Mycin M for injection into a vein (IV infusion), you must use the medicine right away. Do not store for later use.

After mixing Coly Mycin M for injection into a muscle, you may store the mixture in a refrigerator or at cool room temperature. Do not freeze. Use within 7 days.

Coly Mycin M must be given slowly. Your IV infusion may take 3 to 5 minutes to complete. In some cases, this medicine is given over a period of up to 23 hours. Follow your doctor's dosing instructions very carefully.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Coly Mycin M will not treat a viral infection such as the flu or a common cold.

If you need surgery, tell the surgeon ahead of time that you are using Coly Mycin M. You may need to stop using the medicine for a short time.

Store unmixed Coly Mycin M powder at cool room temperature, away from moisture and heat.

Use a disposable needle only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Coly Mycin M can be fatal.

Overdose symptoms may include confusion, dizziness, loss of balance or coordination, severe numbness or tingling, rapid eye movement, problems with speech, weak or shallow breathing, or loss of consciousness.

What should I avoid while using colistimethate?

Coly Mycin M may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

What other drugs will affect Coly Mycin M?

Tell your doctor about all your current medicines and any you start or stop using, especially:

This list is not complete. Other drugs may interact with colistimethate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.