Skip to main content

Coly-Mycin M Dosage

Generic name: COLISTIMETHATE SODIUM 150mg in 2mL
Dosage form: injection
Drug classes: Inhaled anti-infectives, Miscellaneous antibiotics

Medically reviewed by Last updated on Nov 23, 2023.

Important: Coly-Mycin M Parenteral is supplied in vials containing colistimethate sodium equivalent to 150 mg colistin base activity per vial.

Reconstitution for Intravenous or Intramuscular Administration:

The 150 mg vial should be reconstituted with 2 mL Sterile Water for Injection, USP. The reconstituted solution provides colistimethate sodium at a concentration equivalent to 75 mg/mL colistin base activity.

During reconstitution swirl gently to avoid frothing.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. If these conditions are observed, the product should not be used.


Adults and Pediatric Patients—Intravenous or Intramuscular Administration:

The dose of Coly-Mycin M Parenteral should be 2.5 to 5 mg/kg per day of colistin base in 2 to 4 divided doses for patients with normal renal function, depending on the severity of the infection.

In obese individuals, dosage should be based on ideal body weight.

The daily dose and frequency should be reduced for the patients with renal impairment. Suggested modifications of dosage schedule for patients with renal impairment are presented in Table 1.

  • TABLE 1. Suggested Modification of Dosage Schedules of Coly-Mycin M Parenteral for Adults with Impaired Renal Function
Degree of Renal Impairment
Normal Mild Moderate Severe
Note: The suggested total daily dose is calculated from colistin base activity.

Creatinine Clearance (mL/min)





Dosage Schedule

2.5 – 5 mg/kg, divided into 2 to 4 doses per day

2.5 – 3.8 mg/kg, divided into 2 doses per day

2.5 mg/kg, once daily or divided into 2 doses per day

1.5 mg/kg every 36 hours


  • 1.Direct Intermittent Administration—Slowly inject one-half of the total daily dose over a period of 3 to 5 minutes every 12 hours.
  • 2.Continuous Infusion—Slowly inject one-half of the total daily dose over 3 to 5 minutes. Add the remaining half of the total daily dose of Coly-Mycin M Parenteral to one of the following:
    0.9% NaCI
    5% dextrose in 0.9% NaCl
    5% dextrose in water
    5% dextrose in 0.45% NaCl
    5% dextrose in 0.225% NaCl
    lactated Ringer's solution
    10% invert sugar solution

There are not sufficient data to recommend usage of Coly-Mycin M Parenteral with other drugs or other than the above listed infusion solutions.

Administer the second half of the total daily dose by slow intravenous infusion, starting 1 to 2 hours after the initial dose, over the next 22 to 23 hours. In the presence of impaired renal function, reduce the infusion rate depending on the degree of renal impairment.

The choice of intravenous solution and the volume to be employed are dictated by the requirements of fluid and electrolyte management.

Any final intravenous infusion solution containing colistimethate sodium should be freshly prepared and used for no longer than 24 hours.


  • 1.For intramuscular Injection, administer by deep intramuscular injection into a large muscle mass (such as the gluteal muscles or lateral part of the thigh).

Store reconstituted solution for intramuscular injection in a refrigerator 2° to 8°C (36° to 46°F) or between 20° to 25°C (68° to 77°F) and use within 7 days.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.