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Lampit

Generic Name: nifurtimox
Dosage Form: tablets, for oral use

Medically reviewed by Judith Stewart, BPharm. Last updated on Aug 9, 2020.

What is Lampit?

Lampit is a prescription medicine used to treat Chagas disease caused by the parasite Trypanosoma cruzi in children less than 18 years of age weighing at least 5.5 pounds (2.5 kg).
It is not known if this medicine is safe and effective in children weighing less than 5.5 pounds (2.5 kg).

Who should not take Lampit?

Do not take Lampit if you:

  • are allergic to nifurtimox, or any of the ingredients in Lampit. See the end of this page for a complete list of ingredients.
  • plan to drink alcohol during treatment with Lampit.

Before taking Lampit

Before taking Lampit, tell your healthcare provider about all your medical conditions, including if you:

  • have a history of brain injury, seizures, mental health problems, or behavior changes.
  • have kidney problems or are on dialysis.
  • have liver problems.
  • have a genetic problem called porphyria. Taking Lampit can make your symptoms of porphyria including dark urine, severe stomach pain, muscle pain, tingling, numbness, mental changes or skin sensitivity to light worse.
  • are pregnant, plan to become pregnant, or think you may be pregnant. Lampit can harm your unborn baby.
    For females who are able to become pregnant:
    • Your healthcare provider should do a pregnancy test before you start taking Lampit to make sure that you are not pregnant.
    • You should use effective forms of birth control during treatment, and for 6 months after your last dose. Talk to your healthcare provider about what forms of birth control may be right for you.
    • Call your healthcare provider right away if you become pregnant or think you are pregnant during treatment.

For males:

    • Lampit may cause fertility problems in males. This may affect your ability to father a child. Talk to your healthcare provider if you have concerns about fertility.
    • You should use a condom with female partners who are able to become pregnant, during treatment, and for 3 months after your last dose.
  • are breastfeeding or plan to breastfeed. Lampit can pass into breast milk and may harm your baby. Talk to your healthcare provider about the best way to feed your baby during treatment. If you take Lampit and breastfeed, monitor your baby for vomiting, rash, decreased appetite, fever, and irritability.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Know the medicines you take. Keep a list of them with you to show to your healthcare provider and pharmacist when you get a new medicine.

How should I take Lampit?

See the Instructions for Use leaflet that comes with Lampit for information about how to split Lampit tablets and how to take Lampit if whole tablets or half tablets cannot be swallowed.

  • Take Lampit exactly as your healthcare provider tells you.
  • Your healthcare provider may change your dose if needed.
  • Take your prescribed dose of Lampit 3 times a day with food.
  • Lampit tablets are marked with a scored line. Lampit tablets can be taken whole or split at the scored line.
  • Lampit tablets should be split by hand at the scored line. Do not split Lampit tablets using a tablet splitting device.
  • If you cannot swallow Lampit tablets or you are giving Lampit to a child who cannot swallow the tablets, be sure to read the Instructions for Use that come with Lampit. Lampit tablets can be dissolved in water if whole tablets or half tablets cannot be swallowed.
  • If you miss a dose of Lampit, take it as soon as possible with food. If it is within 3 hours of your next scheduled dose, skip the missed dose and take the next dose at your regular time. Do not take 2 doses to make up for a missed dose.

Lampit side effects

Lampit may cause serious side effects, including:

  • Worsening of symptoms related to brain injury, seizures, mental health problems or behavior changes in people with a history of these problems. Call your healthcare provider right away if any of these problems get worse during treatment.
  • Allergic reactions. Allergic reactions can happen when taking nifurtimox, the active ingredient in Lampit, or with changes in your immune system caused by Chagas disease during treatment with Lampit. These allergic reactions can include low blood pressure, swelling of the face and tongue (angioedema), shortness of breath, itching, rash or other skin problems. Call your healthcare provider or get emergency medical help if you get any of these signs and symptoms of an allergic reaction during treatment.
  • Loss of appetite and weight loss. Your healthcare provider should check your weight every 14 days to see if your dose may need to be changed.

The most common side effects include:

  • headache
  • vomiting
  • nausea
  • rash
  • decreased appetite
  • abdominal pain
  • fever

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store Lampit?

  • Store Lampit at room temperature between 68°F to 77°F (20°C to 25°C).
  • Keep Lampit in the bottle that it comes in with the child-resistant cap on the bottle. Do not remove the packet that helps to keep your medicine dry (desiccant).
  • Keep the bottle tightly closed and protect from moisture.
  • Keep Lampit and all medicines out of the reach of children.

General information about the safe and effective use of Lampit.

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use this medicine for a condition for which it was not prescribed. Do not give it to other people, even if they have the same symptoms that you have. It may harm them. You can ask your healthcare provider or pharmacist for information that is written for health professionals.

What are the ingredients in Lampit?

Active ingredient: nifurtimox
Inactive ingredients: calcium hydrogen phosphate dihydrate, magnesium stearate, maize starch, silica colloidal anhydrous, and sodium lauryl sulfate.

INSTRUCTIONS FOR USE

This Instructions for Use contains information on how to split Lampit tablets and how to prepare a tablet and water mixture (called a slurry) if whole tablets or half tablets cannot be swallowed. Read this Instructions for Use before you start taking Lampit and each time you get a refill. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or treatment.

Important Information You Need to Know Before Taking Lampit

  • Do not take more Lampit than prescribed by your healthcare provider.
  • Take Lampit with food.
  • Split Lampit tablets by hand. Do not split Lampit tablets using a tablet splitting device. See the instructions below for splitting tablets by hand.
  • If you cannot swallow Lampit tablets or you are giving Lampit to a child who cannot swallow the tablets, you can dissolve the tablet in water and give the mixture with food. See the instructions below for preparing a tablet and water mixture (slurry).

How to Take Lampit

  • Take Lampit 3 times a day with food.
  • Your healthcare provider may need to change your dose during treatment as needed. Take your dose exactly as prescribed by your healthcare provider. Lampit 30 mg tablets and 120 mg tablets have a scored line on one side and can be taken whole or broken at the scored line.
  • If you miss a dose, take the missed dose as soon as possible with food. If it is within 3 hours of the next scheduled dose, skip the missed dose and take the next dose at your regular time. Do not take 2 doses to make up for a missed dose.

How to Split Lampit Tablets by Hand

Step 1: To split the tablet, place the tablet on a flat surface with the scored line facing up.

Step 2: With the tablet still on the flat surface, apply enough pressure down on the center of the tablet with your index finger to split it in half along the scored line.

Step 3: Lampit tablets can be split in half along the scored line.

Step 4: Only use a tablet that has been broken at the scored line. Do not split the tablets in any other way.

Preparing a Tablet and Water Mixture (Slurry)

For people who are not able to swallow whole tablets or half tablets, Lampit can be mixed in water.

Step 1: Place approximately one-half teaspoonful (2.5 mL) of water into a spoon.

Step 2: Place the prescribed dose into the water.

Step 3: Allow the tablet to dissolve in the water. This should take less than 30 seconds.

Step 4: A tablet and water mixture (slurry) will form.

Give the tablet and water mixture (slurry) right away with food. Do not mix more than the prescribed dose.

Storing Lampit

  • Store Lampit at room temperature between 68°F to 77°F (20°C to 25°C).
  • Keep Lampit in the bottle with child-resistant cap that it comes with. Do not remove the packet tha thelps to keep your medicine dry (desiccant).
  • Keep the bottle tightly closed and protect from moisture.

Keep Lampit and all medicines out of the reach of children.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.