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Pitavastatin Dosage

Applies to the following strengths: 1 mg; 2 mg; 4 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for Hyperlipidemia

Initial dose: 2 mg orally once a day
Maintenance dose: 1 mg to 4 mg orally once a day
Maximum dose: 4 mg/day

Comments:
-Doses greater than 4 mg once a day have been associated with an increased risk for severe myopathy in premarketing studies and thus doses should not exceed 4 mg/day.

Use: As an adjunct to diet to reduce total cholesterol, low density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), and triglycerides, and to increase high density lipoprotein cholesterol (HDL-C) in patients with primary hyperlipidemia or mixed dyslipidemia

Usual Adult Dose for Dyslipidemia

Initial dose: 2 mg orally once a day
Maintenance dose: 1 mg to 4 mg orally once a day
Maximum dose: 4 mg/day

Comments:
-Doses greater than 4 mg once a day have been associated with an increased risk for severe myopathy in premarketing studies and thus doses should not exceed 4 mg/day.

Use: As an adjunct to diet to reduce total cholesterol, low density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), and triglycerides, and to increase high density lipoprotein cholesterol (HDL-C) in patients with primary hyperlipidemia or mixed dyslipidemia

Renal Dose Adjustments

Moderate to severe renal dysfunction (not receiving hemodialysis [GFR 15 to 59 mL/min/1.73 m2]):
-Initial dose: 1 mg orally once a day
-Maximum dose: 2 mg orally once a day

Liver Dose Adjustments

Active liver disease (including unexplained persistent elevations in hepatic transaminase levels): Contraindicated

Dose Adjustments

Concomitant use with erythromycin:
-Maximum dose: 1 mg orally once a day

Concomitant use with rifampin:
-Maximum dose: 2 mg orally once a day

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

ESRD receiving hemodialysis:
-Initial dose: 1 mg orally once a day
-Maximum dose: 2 mg orally once a day

Other Comments

Administration advice:
-Take orally once a day, at any time of day, with or without food

Storage requirements:
-Protect from light.

General:
-This drug has not been studied in Fredrickson Type I, III, and V dyslipidemias.
-Dosages should be individualized according to patient characteristics, including goals of therapy and response to therapy.
-This drug should be used in addition to a diet restricted in saturated fat and cholesterol and only when response to diet and other nonpharmacologic measures alone has been inadequate.

Monitoring:
-Hepatic: Measure liver enzymes prior to initiating therapy and repeat if signs/symptoms of liver injury occur.
-Metabolic: Following initiation or upon titration, lipid levels should be measured after 4 weeks and the dose adjusted accordingly.

Patient advice:
-Report immediately any unexplained muscle pain, tenderness, or weakness, especially if accompanied by malaise or fever, or if muscle signs/symptoms persist after discontinuing therapy.
-Promptly report any symptoms that may be indicative of liver injury, including fatigue, anorexia, right upper abdominal discomfort, dark urine, or jaundice.
-Contraceptive methods should be used while taking this drug.
-Talk to your health care provider if you are pregnant, planning to become pregnant, or breastfeeding; this drug is not recommended for use during pregnancy or in nursing mothers.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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