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Pitavastatin Dosage

Applies to the following strength(s): 1 mg ; 2 mg ; 4 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Hyperlipidemia

Initial dose: 2 mg orally once a day
Maintenance dose: 1 mg to 4 mg orally once a day
Maximum dose: 4 mg/day

Comments:
-Doses greater than 4 mg once a day have been associated with an increased risk for severe myopathy in premarketing studies and thus doses should not exceed 4 mg/day.

Use: As an adjunct to diet to reduce total cholesterol, low density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), and triglycerides, and to increase high density lipoprotein cholesterol (HDL-C) in patients with primary hyperlipidemia or mixed dyslipidemia

Usual Adult Dose for Dyslipidemia

Initial dose: 2 mg orally once a day
Maintenance dose: 1 mg to 4 mg orally once a day
Maximum dose: 4 mg/day

Comments:
-Doses greater than 4 mg once a day have been associated with an increased risk for severe myopathy in premarketing studies and thus doses should not exceed 4 mg/day.

Use: As an adjunct to diet to reduce total cholesterol, low density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), and triglycerides, and to increase high density lipoprotein cholesterol (HDL-C) in patients with primary hyperlipidemia or mixed dyslipidemia

Renal Dose Adjustments

Moderate to severe renal dysfunction (not receiving hemodialysis [GFR 15 to 59 mL/min/1.73 m2]):
-Initial dose: 1 mg orally once a day
-Maximum dose: 2 mg orally once a day

Liver Dose Adjustments

Active liver disease (including unexplained persistent elevations in hepatic transaminase levels): Contraindicated

Dose Adjustments

Concomitant use with erythromycin:
-Maximum dose: 1 mg orally once a day

Concomitant use with rifampin:
-Maximum dose: 2 mg orally once a day

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

ESRD receiving hemodialysis:
-Initial dose: 1 mg orally once a day
-Maximum dose: 2 mg orally once a day

Other Comments

Administration advice:
-Take orally once a day, at any time of day, with or without food

Storage requirements:
-Protect from light.

General:
-This drug has not been studied in Fredrickson Type I, III, and V dyslipidemias.
-Dosages should be individualized according to patient characteristics, including goals of therapy and response to therapy.
-This drug should be used in addition to a diet restricted in saturated fat and cholesterol and only when response to diet and other nonpharmacologic measures alone has been inadequate.

Monitoring:
-Hepatic: Measure liver enzymes prior to initiating therapy and repeat if signs/symptoms of liver injury occur.
-Metabolic: Following initiation or upon titration, lipid levels should be measured after 4 weeks and the dose adjusted accordingly.

Patient advice:
-Report immediately any unexplained muscle pain, tenderness, or weakness, especially if accompanied by malaise or fever, or if muscle signs/symptoms persist after discontinuing therapy.
-Promptly report any symptoms that may be indicative of liver injury, including fatigue, anorexia, right upper abdominal discomfort, dark urine, or jaundice.
-Contraceptive methods should be used while taking this drug.
-Talk to your health care provider if you are pregnant, planning to become pregnant, or breastfeeding; this drug is not recommended for use during pregnancy or in nursing mothers.

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