Nipride RTU Dosage
Medically reviewed by Drugs.com. Last updated on Jul 11, 2022.
Inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever solution and container permit. Sodium nitroprusside should be a clear colorless to red/brown color; do not use if solution is blue, green, or bright red.
Continuously monitor blood pressure in patients receiving sodium nitroprusside. Start infusion of sodium nitroprusside at a rate of 0.3 mcg/kg/min. Evaluate blood pressure for at least 5 minutes before titrating to a higher or lower dose to achieve the desired blood pressure. The dose may be titrated upward until:
- the desired effect is achieved,
- systemic blood pressure cannot be further reduced without compromising the perfusion of vital organs, or
- the maximum recommended infusion rate of 10 mcg/kg/min has been reached, whichever occurs first.
In patients with eGFR <30 mL/min/1.73 m2, limit the mean infusion rate to less than 3 mcg/kg/min. In anuric patients, limit the mean infusion rate to 1 mcg/kg/min.
Do not administer other drugs in the same solution with sodium nitroprusside.
Sodium nitroprusside must be delivered by a volumetric infusion pump because small variations in infusion rate can lead to wide, undesirable variations in blood pressure [see Clinical Pharmacology (12.2)].
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