Ledipasvir / Sofosbuvir Dosage
Applies to the following strength(s): 90 mg-400 mg
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Chronic Hepatitis C
1 tablet orally once a day
Duration of Therapy:
-Therapy-naive patients without cirrhosis: 12 weeks; 8 weeks can be considered if pretreatment HCV RNA less than 6 million international units/mL
-Therapy-naive patients with cirrhosis: 12 weeks
-Therapy-experienced patients without cirrhosis: 12 weeks
-Therapy-experienced patients with cirrhosis: 24 weeks
-Relapse rates are affected by baseline host and viral factors and differ between durations of therapy for some subgroups.
-Therapy-experienced patients are those patients who have failed treatment with either peginterferon alfa/ribavirin or peginterferon alfa/ribavirin/HCV protease inhibitor.
Use: For the treatment of chronic hepatitis C genotype 1 infection
Renal Dose Adjustments
Mild or moderate renal dysfunction: No adjustment recommended.
Severe renal dysfunction (estimated glomerular filtration rate less than 30 mL/min/1.73 m2): Data not available
Comments: Safety and efficacy have not been established in patients with severe renal dysfunction; dose not established due to higher exposures of the main sofosbuvir metabolite.
Liver Dose Adjustments
Mild, moderate, or severe liver dysfunction (Child-Pugh A, B, or C): No adjustment recommended.
Comments: Safety and efficacy not established in patients with decompensated cirrhosis.
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
End-stage renal disease (ESRD) requiring hemodialysis: Data not available
Comments: Safety and efficacy have not been established in ESRD patients requiring hemodialysis; dose not established due to higher exposures of the main sofosbuvir metabolite.
-May take without regard to food
-Consult the manufacturer product information regarding missed doses.
-Store in the original container at room temperature below 30C (86F)
More about ledipasvir/sofosbuvir
- Other brands: Harvoni